2020年5月
Synthetic mRNA-Based Systems in Mammalian Cells.
Advanced biosystems
- ,
- ,
- 巻
- 4
- 号
- 5
- 開始ページ
- e1900247
- 終了ページ
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1002/adbi.201900247
Living organisms are programmed to perform multiple functions by sensing intra- and extra-cellular environments and by controlling gene expressions. Synthetic biologists aim to program cells by mimicking, designing, and constructing genetic circuits. Synthetic mRNA-based genetic switches and circuits have attracted attention for future therapeutic applications because of their safety and functional diversity. Here, the mRNA-based switches and circuits that detect specific microRNAs or proteins expressed in a target cell to control transgene expression and cell fate are reviewed. Future perspectives of artificial RNA systems for cell engineering will also be addressed.
- ID情報
-
- DOI : 10.1002/adbi.201900247
- PubMed ID : 32402126