論文

国際誌
2021年9月24日

A human biomonitoring (HBM) Global Registry Framework: Further advancement of HBM research following the FAIR principles.

International journal of hygiene and environmental health
  • Maryam Zare Jeddi
  • Ana Virgolino
  • Peter Fantke
  • Nancy B Hopf
  • Karen S Galea
  • Sylvie Remy
  • Susana Viegas
  • Vicente Mustieles
  • Mariana F Fernandez
  • Natalie von Goetz
  • Joana Lobo Vicente
  • Jaroslav Slobodnik
  • Loïc Rambaud
  • Sébastien Denys
  • Annie St-Amand
  • Shoji F Nakayama
  • Tiina Santonen
  • Robert Barouki
  • Robert Pasanen-Kase
  • Hans G J Mol
  • Theo Vermeire
  • Kate Jones
  • Maria João Silva
  • Henriqueta Louro
  • Hilko van der Voet
  • Radu-Corneliu Duca
  • Hans Verhagen
  • Cristina Canova
  • Jacob van Klaveren
  • Marike Kolossa-Gehring
  • Jos Bessems
  • 全て表示

238
開始ページ
113826
終了ページ
113826
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1016/j.ijheh.2021.113826

Data generated by the rapidly evolving human biomonitoring (HBM) programmes are providing invaluable opportunities to support and advance regulatory risk assessment and management of chemicals in occupational and environmental health domains. However, heterogeneity across studies, in terms of design, terminology, biomarker nomenclature, and data formats, limits our capacity to compare and integrate data sets retrospectively (reuse). Registration of HBM studies is common for clinical trials; however, the study designs and resulting data collections cannot be traced easily. We argue that an HBM Global Registry Framework (HBM GRF) could be the solution to several of challenges hampering the (re)use of HBM (meta)data. The aim is to develop a global, host-independent HBM registry framework based on the use of harmonised open-access protocol templates from designing, undertaking of an HBM study to the use and possible reuse of the resulting HBM (meta)data. This framework should apply FAIR (Findable, Accessible, Interoperable and Reusable) principles as a core data management strategy to enable the (re)use of HBM (meta)data to its full potential through the data value chain. Moreover, we believe that implementation of FAIR principles is a fundamental enabler for digital transformation within environmental health. The HBM GRF would encompass internationally harmonised and agreed open access templates for HBM study protocols, structured web-based functionalities to deposit, find, and access harmonised protocols of HBM studies. Registration of HBM studies using the HBM GRF is anticipated to increase FAIRness of the resulting (meta)data. It is also considered that harmonisation of existing data sets could be performed retrospectively. As a consequence, data wrangling activities to make data ready for analysis will be minimised. In addition, this framework would enable the HBM (inter)national community to trace new HBM studies already in the planning phase and their results once finalised. The HBM GRF could also serve as a platform enhancing communication between scientists, risk assessors, and risk managers/policy makers. The planned European Partnership for the Assessment of Risk from Chemicals (PARC) work along these lines, based on the experience obtained in previous joint European initiatives. Therefore, PARC could very well bring a first demonstration of first essential functionalities within the development of the HBM GRF.

リンク情報
DOI
https://doi.org/10.1016/j.ijheh.2021.113826
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/34583227
ID情報
  • DOI : 10.1016/j.ijheh.2021.113826
  • PubMed ID : 34583227

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