論文

査読有り
2014年4月

Generation of colonic IgA-secreting cells in the caecal patch

NATURE COMMUNICATIONS
  • Kazunori Masahata
  • Eiji Umemoto
  • Hisako Kayama
  • Manato Kotani
  • Shota Nakamura
  • Takashi Kurakawa
  • Junichi Kikuta
  • Kazuyoshi Gotoh
  • Daisuke Motooka
  • Shintaro Sato
  • Tomonori Higuchi
  • Yoshihiro Baba
  • Tomohiro Kurosaki
  • Makoto Kinoshita
  • Yosuke Shimada
  • Taishi Kimura
  • Ryu Okumura
  • Akira Takeda
  • Masaru Tajima
  • Osamu Yoshie
  • Masahiro Fukuzawa
  • Hiroshi Kiyono
  • Sidonia Fagarasan
  • Tetsuya Iida
  • Masaru Ishii
  • Kiyoshi Takeda
  • 全て表示

5
開始ページ
3704
終了ページ
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1038/ncomms4704
出版者・発行元
NATURE PUBLISHING GROUP

Gut-associated lymphoid tissues are responsible for the generation of IgA-secreting cells. However, the function of the caecal patch, a lymphoid tissue in the appendix, remains unknown. Here we analyse the role of the caecal patch using germ-free mice colonized with intestinal bacteria after appendectomy. Appendectomized mice show delayed accumulation of IgA(+) cells in the large intestine, but not the small intestine, after colonization. Decreased colonic IgA(+) cells correlate with altered faecal microbiota composition. Experiments using photoconvertible Kaede-expressing mice or adoptive transfer show that the caecal patch IgA(+) cells migrate to the large and small intestines, whereas Peyer's patch cells are preferentially recruited to the small intestine. IgA(+) cells in the caecal patch express higher levels of CCR10. Dendritic cells in the caecal patch, but not Peyer's patches, induce CCR10 on cocultured B cells. Thus, the caecal patch is a major site for generation of IgA-secreting cells that migrate to the large intestine.

リンク情報
DOI
https://doi.org/10.1038/ncomms4704
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/24718324
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000335222700002&DestApp=WOS_CPL
ID情報
  • DOI : 10.1038/ncomms4704
  • ISSN : 2041-1723
  • PubMed ID : 24718324
  • Web of Science ID : WOS:000335222700002

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