Kyota Fujita

Profile Information

Affiliation: Research Center for Child Mental Development, Kanazawa University
: -

Degree: 博士

J-GLOBAL ID: 201101005381999252
researchmap Member ID: B000003101

Research Interests

Research Areas

Research History

Apr, 2022 - Present

Research Center for Child Mental Development, Kanazawa University
Apr, 2022 - Present

Tokyo Medical and Dental University
Apr, 2021 - Mar, 2022

講師, 東京医科歯科大学難治疾患研究所神経病理学分野
Apr, 2016 - Mar, 2021

Medical Research Institute, Tokyo Medical and Dental University
Apr, 2012 - Mar, 2016

Medical Research Institute, Tokyo Medical and Dental University
Apr, 2011 - Mar, 2012

PD, 日本学術振興会特別研究員
Apr, 2008 - Mar, 2011

Graduate School of Pharmaceutical Sciences, Kyushu University
Apr, 2006 - Mar, 2008

Graduate School of Pharmaceutical Sciences, Kyushu University

Awards

Oct, 2019

優秀研究賞, 東京医科歯科大学
May, 2019

Best Free Paper Oral Presentation (Basic Research) for JSN members, Targeting Tyro3 ameliorates a model of PGRN-mutant FTLD-TDP via tau-mediated synaptic pathology, The Japanese Society of Neurology
Mar, 2019

最優秀論文賞, 東京医科歯科大学難治疾患研究所

藤田慶大
Mar, 2018

優秀論文賞, 東京医科歯科大学難治疾患研究所

藤田慶大
Mar, 2013

優秀論文賞, 東京医科歯科大学難治疾患研究所

藤田慶大
Apr, 2009

九州大学学生後援会学術研究賞, 九州大学後援会

藤田慶大
Jan, 2009

日本病態生理学会優秀奨励賞, 日本病態生理学会

藤田慶大
Oct, 2008

日本生理学会九州奨励賞, 日本生理学会

藤田慶大

Papers

PQBP5/NOL10 maintains and anchors the nucleolus under physiological and osmotic stress conditions.

Xiaocen Jin, Hikari Tanaka, Meihua Jin, Kyota Fujita, Hidenori Homma, Maiko Inotsume, Huang Yong, Kenichi Umeda, Noriyuki Kodera, Toshio Ando, Hitoshi Okazawa

Nature communications, 14(1) 9-9, Jan 4, 2023
PQBP5/NOL10 maintains and anchors the nucleolus under physiological and osmotic stress conditions

Xiaocen Jin, Hikari Tanaka, Meihua Jin, Kyota Fujita, Hidenori Homma, Maiko Inotsume, Huang Yong, Kenichi Umeda, Noriyuki Kodera, Toshio Ando, Hitoshi Okazawa

Nature Communications, 14(1), Jan 4, 2023
Autoantibodies against NCAM1 from patients with schizophrenia cause schizophrenia-related behavior and changes in synapses in mice.

Hiroki Shiwaku, Shingo Katayama, Kanoh Kondo, Yuri Nakano, Hikari Tanaka, Yuki Yoshioka, Kyota Fujita, Haruna Tamaki, Hironao Takebayashi, Omi Terasaki, Yukihiro Nagase, Teruyoshi Nagase, Tetsuo Kubota, Kinya Ishikawa, Hitoshi Okazawa, Hidehiko Takahashi

Cell reports. Medicine, 3(4) 100597-100597, Apr 19, 2022
HMGB1 signaling phosphorylates Ku70 and impairs DNA damage repair in Alzheimer's disease pathology.

Hikari Tanaka, Kanoh Kondo, Kyota Fujita, Hidenori Homma, Kazuhiko Tagawa, Xiaocen Jin, Meihua Jin, Yuki Yoshioka, Sumire Takayama, Hitomi Masuda, Rie Tokuyama, Yukoh Nakazaki, Takashi Saito, Takaomi Saido, Shigeo Murayama, Teikichi Ikura, Nobutoshi Ito, Yu Yamamori, Kentaro Tomii, Marco E Bianchi, Hitoshi Okazawa

Communications biology, 4(1) 1175-1175, Oct 11, 2021
胎児期神経幹細胞のDNA損傷が早期神経細胞ネクローシスを介してFTLD発症を運命付ける

藤田慶大, 本間秀典, 田中ひかり, Jin Meihua, Jin Xiaocen, Huang Yong, 吉岡優希, 近藤和, 塩飽裕紀, 田川一彦, 曽根雅紀, 岡澤均

Dementia Japan, 35(4) 609-609, Oct, 2021
Hepta-Histidine Inhibits Tau Aggregation.

Kanoh Kondo, Teikichi Ikura, Hikari Tanaka, Kyota Fujita, Sumire Takayama, Yuki Yoshioka, Kazuhiko Tagawa, Hidenori Homma, Su Liu, Ryosuke Kawasaki, Yong Huang, Nobutoshi Ito, Shin-Ichi Tate, Hitoshi Okazawa

ACS chemical neuroscience, 12(16) 3015-3027, Aug 18, 2021
Prediction and verification of the AD-FTLD common pathomechanism based on dynamic molecular network analysis.

Meihua Jin, Xiaocen Jin, Hidenori Homma, Kyota Fujita, Hikari Tanaka, Shigeo Murayama, Hiroyasu Akatsu, Kazuhiko Tagawa, Hitoshi Okazawa

Communications biology, 4(1) 961-961, Aug 12, 2021
DNA damage in embryonic neural stem cell determines FTLDs’ fate via early-stage neuronal necrosis

Hidenori Homma, Hikari Tanaka, Meihua Jin, Xiaocen Jin, Yong Huang, Yuki Yoshioka, Christian JF Bertens, Kohei Tsumaki, Kanoh Kondo, Hiroki Shiwaku, Kazuhiko Tagawa, Hiroyasu Akatsu, Naoki Atsuta, Masahisa Katsuno, Katsutoshi Furukawa, Aiko Ishiki, Masaaki Waragai, Gaku Ohtomo, Atsushi Iwata, Takanori Yokota, Haruhisa Inoue, Hiroyuki Arai, Gen Sobue, Masaki Sone, Kyota Fujita, Hitoshi Okazawa

Life Science Alliance, 4(7) e202101022-e202101022, Jul, 2021 Lead author
Role of the Drosophila YATA protein in the proper subcellular localization of COPI revealed by in vivo analysis

Maiko Saito, Minoru Nakayama, Kyota Fujita, Atsuko Uchida, Hiroyuki Yano, Satoshi Goto, Hitoshi Okazawa, Masaki Sone

Genes & Genetic Systems, 95(6) 303-314, Dec 1, 2020
YAP-dependent necrosis occurs in early stages of Alzheimer's disease and regulates mouse model pathology.

Hikari Tanaka, Hidenori Homma, Kyota Fujita, Kanoh Kondo, Shingo Yamada, Xiaocen Jin, Masaaki Waragai, Gaku Ohtomo, Atsushi Iwata, Kazuhiko Tagawa, Naoki Atsuta, Masahisa Katsuno, Naoki Tomita, Katsutoshi Furukawa, Yuko Saito, Takashi Saito, Ayaka Ichise, Shinsuke Shibata, Hiroyuki Arai, Takaomi Saido, Marius Sudol, Shin-Ichi Muramatsu, Hideyuki Okano, Elliott J Mufson, Gen Sobue, Shigeo Murayama, Hitoshi Okazawa

Nature communications, 11(1) 507-507, Jan 24, 2020 Peer-reviewed
PQBP1, an intellectual disability causative gene, affects bone development and growth.

Shin-Sheng Yang, Takayoshi Ishida, Kyota Fujita, Yuta Nakai, Takashi Ono, Hitoshi Okazawa

Biochemical and biophysical research communications, 523(4) 894-899, Jan 17, 2020 Peer-reviewed
発達障害原因遺伝子PQBP1はアルツハイマー病態を制御する

田中ひかり, 近藤和, 陳西貴, 田川一彦, Kerever Aurelian, 青木茂樹, 斉藤貴志, 西道隆臣, 村松慎一, 藤田慶大, 岡澤均

臨床神経学, 59(Suppl.) S461-S461, Nov, 2019 Peer-reviewed
Drebrin-like (Dbnl) Controls Neuronal Migration via Regulating N-Cadherin Expression in the Developing Cerebral Cortex.

Seika Inoue, Kanehiro Hayashi, Kyota Fujita, Kazuhiko Tagawa, Hitoshi Okazawa, Ken-Ichiro Kubo, Kazunori Nakajima

The Journal of neuroscience : the official journal of the Society for Neuroscience, 39(4) 678-691, Jan 23, 2019 Peer-reviewed
The intellectual disability gene PQBP1 rescues Alzheimer's disease pathology.

Hikari Tanaka, Kanoh Kondo, Xigui Chen, Hidenori Homma, Kazuhiko Tagawa, Aurelian Kerever, Shigeki Aoki, Takashi Saito, Takaomi Saido, Shin-Ichi Muramatsu, Kyota Fujita, Hitoshi Okazawa

Molecular psychiatry, 23(10) 2090-2110, Oct, 2018 Peer-reviewed
アルツハイマー病と前頭側頭葉変性症に共通する異常タウリン酸化とシナプス障害

藤田慶大, 陳西貴, 本間秀典, 田川一彦, 岡澤均

Dementia Japan, 32(3) 431-431, Sep, 2018
Ser46-Phosphorylated MARCKS Is a Marker of Neurite Degeneration at the Pre-aggregation Stage in PD/DLB Pathology.

Fujita K, Homma H, Kondo K, Ikuno M, Yamakado H, Tagawa K, Murayama S, Takahashi R, Okazawa H

eNeuro, 5(4) ENEURO.0217-18.2018, Jul, 2018 Peer-reviewedLead author
Mild Maternal Hypothyroxinemia during Pregnancy Induces Persistent DNA Hypermethylation in the Hippocampal Brain-Derived Neurotrophic Factor Gene in Mouse Offspring

Kenichi Kawahori, Koshi Hashimoto, Xunmei Yuan, Kazutaka Tsujimoto, Nozomi Hanzawa, Miho Hamaguchi, Saori Kase, Kyota Fujita, Kazuhiko Tagawa, Hitoshi Okazawa, Yasuyo Nakajima, Nobuyuki Shibusawa, Masanobu Yamada, Yoshihiro Ogawa

Thyroid, 28(3) 395-406, Mar 1, 2018 Peer-reviewed
Targeting Tyro3 ameliorates a model of PGRN-mutant FTLD-TDP via tau-mediated synaptic pathology.

Kyota Fujita, Xigui Chen, Hidenori Homma, Kazuhiko Tagawa, Mutsuki Amano, Ayumu Saito, Seiya Imoto, Hiroyasu Akatsu, Yoshio Hashizume, Kozo Kaibuchi, Satoru Miyano, Hitoshi Okazawa

Nature communications, 9(1) 433-433, Jan 30, 2018 Peer-reviewedLead author
妊娠期甲状腺機能低下マウスからの産仔における行動異常にはBDNFのDNAメチル化亢進が関与している

川堀健一, 橋本貢士, 袁勲梅, 辻本和峰, 榛澤望, 加瀬早織, 藤田慶大, 田川一彦, 岡澤均, 小川佳宏

日本内分泌学会雑誌, 93(4) 1128-1128, Dec, 2017
妊娠期軽度甲状腺機能低下マウスの産仔における行動異常はBDNFのDNAメチル化亢進が関与している

川堀健一, 橋本貢士, 袁勲梅, 辻本和峰, 榛澤望, 藤田慶大, 田川一彦, 岡澤均, 小川佳宏

日本内分泌学会雑誌, 93(4) 1218-1218, Dec, 2017

Misc.

YAP依存的ネクローシスは超早期アルツハイマー病態を制御する

田中ひかり, 田中ひかり, 本間秀典, 藤田慶大, 近藤和, JIN Xiaocen, 田川一彦, 岡澤均

Dementia Japan, 34(4), 2020
発達障害原因遺伝子PQBP1はアルツハイマー病態を制御する

田中ひかり, 田中ひかり, 近藤和, 陳西貴, 本間秀典, 田川一彦, 藤田慶大, 岡澤均

Dementia Japan, 34(4), 2020
凝集前病態の解明に基づくアルツハイマー病の新規DMT 開発

藤田慶大, 岡澤均

アルツハイマー病～発症メカニズムと新規診断法･創薬･治療開発～, Aug, 2018 Peer-reviewedInvitedLead author
軽度甲状腺機能低下母獣マウスの産仔における行動異常とBrain-derived neurotrophic factor(BDNF)遺伝子のDNAメチル化制御

川堀健一, 橋本貢士, 袁勲梅, 辻本和峰, 榛澤望, 藤田慶大, 田川一彦, 岡澤均, 山田正信, 小川佳宏

日本臨床分子医学会学術総会プログラム・抄録集, 55回 69-69, Apr, 2018
アルツハイマー病において神経突起変性を誘発するHMGB1-MARCKSリン酸化シグナル

藤田慶大, 本木和美, 田川一彦, 陳西貴, 本間秀典, 岡澤均

Dementia Japan, 31(4) 562-562, Oct, 2017
chapterIII-4ポリグルタミン病

藤田慶大, 岡澤均

運動失調のみかた、考えかた –小脳と脊髄小脳変性症–, 251-260, Sep, 2017 Peer-reviewedInvitedLead author
発症分子機構update 3.アミロイド凝集前の超早期病態とその抑制

藤田慶大, 岡澤均

実験医学増刊, 35(12) 198-203, Jul, 2017 Peer-reviewedInvitedLead author
変性疾患の共通分子病態

藤田慶大, 岡澤均

生体の科学, 67(4) 309-313, Aug, 2016 Peer-reviewedInvitedLead author
神経変性疾患の共通病態としてのDNA損傷修復異常

藤田慶大, 岡澤均

Annual Review神経2015, 65-72, Jan, 2015 Peer-reviewedInvitedLead author
Omicsからみた神経変性疾患の病態機序

藤田慶大, 岡澤均

医学のあゆみ, 247(5) 401-406, Nov, 2013 Peer-reviewedInvitedLead author
IMPORTANCE OF OLIGODENDROCYTES IN OXIDATIVE STRESS-RESISTANCE IN WHITE MATTER ISCHEMIC INJURY

M. Noda, K. Fujita, M. Hamner, C. Higashi, M. Yamafuji, N. Akimoto, M. Kido, Y. Tanaka, Y. Nakabeppu, B. Ransom

GLIA, 61 S67-S67, Jul, 2013
パーキンソン病モデルマウスにおける水素水の新しい作用機序

山藤芽実, 藤田慶大, 小島佑一郎, 松本明郎, 中別府雄作, 野田百美

日本生理学雑誌, 75(2) 62, Mar 1, 2013
Therapeutic effects of hydrogen in animal models of Parkinson's disease

Kyota Fujita, Yusaku Nakabeppu, Mami Noda

Parkinson's Disease, 2011
LOW CONCENTRATION OF HYDROGEN GAS HAS PROTECTIVE EFFECTS ON DOPAMINERGIC NEURONS IN PARKINSON'S DISEASE MODEL MICE

Kyota Fujita, Toshihiro Seike, Yukiko Yamakawa, Mizuho Ohno, Hiroo Yamaguchi, Hideyuki Yamada, Atsushi Takaki, Mizuho Kido, Yusaku Nakabeppu, Mami Noda

JOURNAL OF PHYSIOLOGICAL SCIENCES, 59 511-511, 2009
Interaction of cancer cells with glial cells in microenvironment of brain metastasis

Iguchi Haruo, Seike Toshihiro, Fujita Kyota, Kido Mizuho, Tanaka Teruo, Noda Mami

CLINICAL & EXPERIMENTAL METASTASIS, 24(4) 294-294, 2007

Presentations

脊髄小脳失調症１型の遺伝子治療

藤田慶大, 岡澤均

第６２回日本神経学会学術大会, May 20, 2021
Targeting Tyro3 ameliorates a model of PGRN-mutant FTLD-TDP via tau-mediated synaptic pathology

Kyota Fujita

60th Annual Meeting of the Japanese Society of Neurology, May 22, 2019
A novel form of necrosis, TRIAD, in Huntington’s disease

Kyota Fujita

Jul 28, 2018
Developmental YAPdeltaC determines adult pathology in a mouse model of spinocerebellarataxia type 1.

藤田慶大

第59回日本神経学会学術大会, May 23, 2018
抗酸化物質としての水素分子：“水素医学”の期待と将来

藤田慶大

第20回日本病態生理学会大会病態生理学会サテライトセミナー, Jan, 2010
Hydrogen in Drinking Water Reduces Dopaminergic Neuronal Loss in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine Mouse Model of Parkinson’s Disease.

藤田慶大

Kyushu Brain Days, International Student Symposium, Nov, 2009
Low concentration of hydrogen gas has protective effects on dopaminergic neurons in Parkinson’s disease model mice.

藤田慶大

IUPS2009, Jul, 2009
MPTP誘発性パーキンソン病モデルマウスに対する水素含有水の効用

藤田慶大

第11回ブレインサイエンス研究会, Jun, 2009
Glial cytokine as a key player in the progression of metastasized tumors in the brain.

藤田慶大

Gordon Research Conference on Glial Biology: Functional Interaction between Glia & Neuron., Mar, 2009
パーキンソン病モデルマウスにおける水素含有飲用水の効果

藤田慶大

第19回日本病態生理学会大会, Jan, 2009
Protective effects of hydrogen in drinking water in a mouse model of Parkinson’’s disease.

藤田慶大

Berlin Brain Days, Dec, 2008
水素水はパーキンソン病モデルマウスにおいてドパミン神経細胞死を抑制する

藤田慶大

第59回西日本生理学会, Oct, 2008
水素水はパーキンソン病モデルマウスにおいてドパミン神経細胞死を抑制する

藤田慶大

第51回日本神経化学会大会, Sep, 2008
肺癌脳転移モデルにおける脳内グリア細胞の相反的役割

藤田慶大

第18回日本病態生理学会大会, Jan, 2007
脳転移における癌細胞と脳微小環境の相互作用：アストロサイトの役割

藤田慶大

第65回日本癌学会学術総会, Sep, 2006
脳転移におけるがん細胞と脳微小環境の相互作用：アストロサイトの役割

藤田慶大

第8回ブレインサイエンス研究会, Jun, 2006

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