論文

2019年11月27日

A specific type of insulin-like peptide regulates the conditional growth of a beetle weapon

PLOS Biology
  • Yasukazu Okada
  • ,
  • Masako Katsuki
  • ,
  • Naoki Okamoto
  • ,
  • Haruna Fujioka
  • ,
  • Kensuke Okada

17
11
開始ページ
e3000541
終了ページ
e3000541
記述言語
掲載種別
研究論文(学術雑誌)
DOI
10.1371/journal.pbio.3000541
出版者・発行元
Public Library of Science (PLoS)

Evolutionarily conserved insulin/insulin-like growth factor (IGF) signaling (IIS) has been identified as a major physiological mechanism underlying the nutrient-dependent regulation of sexually selected weapon growth in animals. However, the molecular mechanisms that couple nutritional state with weapon growth remain largely unknown. Here, we show that one specific subtype of insulin-like peptide (ILP) responds to nutrient status and thereby regulates weapon size in the broad-horned flour beetle Gnatocerus cornutus. By using transcriptome information, we identified five G. cornutus ILP (GcorILP1-5) and two G. cornutus insulin-like receptor (GcorInR1, -2) genes in the G. cornutus genome. RNA interference (RNAi)-mediated gene silencing revealed that a certain subtype of ILP, GcorILP2, specifically regulated weapon size. Importantly, GcorILP2 was highly and specifically expressed in the fat body in a condition-dependent manner. We further found that GcorInR1 and Gcor-InR2 are functionally redundant but that the latter is partially specialized for regulating weapon growth. These results strongly suggest that GcorILP2 is an important component of the developmental mechanism that couples nutritional state to weapon growth in G. cornutus. We propose that the duplication and subsequent diversification of IIS genes played a pivotal role in the evolution of the complex growth regulation of secondary sexual traits.

リンク情報
DOI
https://doi.org/10.1371/journal.pbio.3000541
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/31774806
URL
https://dx.plos.org/10.1371/journal.pbio.3000541
Scopus
https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85075721625&origin=inward 本文へのリンクあり
Scopus Citedby
https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=85075721625&origin=inward
ID情報
  • DOI : 10.1371/journal.pbio.3000541
  • ISSN : 1544-9173
  • eISSN : 1545-7885
  • PubMed ID : 31774806
  • SCOPUS ID : 85075721625

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