論文

国際誌
2022年3月11日

Characterization and preliminary in vivo evaluation of a self-expandable hydrogel stent with anisotropic swelling behavior and endoscopic deliverability for use in biliary drainage.

Journal of materials chemistry. B
  • Yoshiyasu Nagakawa
  • ,
  • Satoshi Fujita
  • ,
  • Shunji Yunoki
  • ,
  • Takayoshi Tsuchiya
  • ,
  • Shin-Ichiro Suye
  • ,
  • Kenji Kinoshita
  • ,
  • Motoki Sasaki
  • ,
  • Takao Itoi

記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1039/d2tb00104g
出版者・発行元
ROYAL SOC CHEMISTRY

We demonstrate the potential of a novel self-expandable biliary stent comprised of poly(vinyl alcohol) (PVA) hydrogel with anisotropic swelling behavior and endoscopic deliverability in vivo, using a porcine stent model. The mechanism underlying the anisotropic swelling behavior and endoscopic deliverability (i.e., flexibility) was investigated by scanning electron microscopy (SEM), small-angle X-ray scattering (SAXS), evaluation of the water content and swelling ratio, and three-point bending tests. The in vivo experiment using a porcine stent model indicated that the tube-shaped PVA hydrogel could effectively expand the biliary tract, without disturbing bile flow. SEM and SAXS showed that PVA hydrogels prepared by drying under extension showed structural orientation along the extension axis, leading to anisotropic swelling. The water content of the PVA hydrogel was found to be crucial for maintaining flexibility as well as endoscopic deliverability. In conclusion, this study demonstrated the novel concept of using a hydrogel stent as a self-expandable biliary stent.

リンク情報
DOI
https://doi.org/10.1039/d2tb00104g
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/35274668
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000767366400001&DestApp=WOS_CPL
ID情報
  • DOI : 10.1039/d2tb00104g
  • ISSN : 2050-750X
  • eISSN : 2050-7518
  • ORCIDのPut Code : 109692928
  • PubMed ID : 35274668
  • Web of Science ID : WOS:000767366400001

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