論文

査読有り
2018年1月1日

Highly activated PD-1/PD-L1 pathway in gastric cancer with PD-L1 expression

Anticancer Research
  • Hiroaki Saito
  • ,
  • Yusuke Kono
  • ,
  • Yuki Murakami
  • ,
  • Yuji Shishido
  • ,
  • Hirohiko Kuroda
  • ,
  • Tomoyuki Matsunaga
  • ,
  • Yoji Fukumoto
  • ,
  • Tomohiro Osaki
  • ,
  • Keigo Ashida
  • ,
  • Yoshiyuki Fujiwara

38
1
開始ページ
107
終了ページ
112
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.21873/anticanres.12197
出版者・発行元
International Institute of Anticancer Research

Background: A recent study demonstrated that immune-checkpoint molecules are associated with tumoral immune evasion. Materials and Methods: Programmed cell death protein 1 (PD-1) expression on CD4+ and CD8+ T-cells obtained from gastric cancer tissue was evaluated by multicolor flow cytometry. Immunohistochemical staining was also performed to evaluate programmed cell death ligand-1 (PD-L1) expression on gastric cancer cells. Results: There were statistically significant correlations between PD-L1 expression and age, histology, tumor size, depth of invasion, lymph node metastasis, lymphatic vessel invasion, venous invasion, and disease stage. The 5-year survival rates of patients with and without PD-L1-positive tumors were 48.9% and 80.7%, respectively, and the difference was statistically significant. Multivariate analysis indicated that PD-L1 expression was an independent prognostic indicator. The frequency of PD-1-positive CD4+ and CD8+ T-cells from gastric cancer tissue with PD-L1 expression was significantly more than that from gastric cancer tissue without PD-L1 expression. Conclusion: PD-L1 expression was related to a poor prognosis in patients with gastric cancer. Furthermore, PD-1 expression on T-cells was upregulated in patients with tumors with PD-L1 expression.

リンク情報
DOI
https://doi.org/10.21873/anticanres.12197
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/29277762
ID情報
  • DOI : 10.21873/anticanres.12197
  • ISSN : 1791-7530
  • ISSN : 0250-7005
  • PubMed ID : 29277762
  • SCOPUS ID : 85039806301

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