論文

査読有り
2018年3月1日

Combined analysis of the pre- and postoperative neutrophil–lymphocyte ratio predicts the outcomes of patients with gastric cancer

Surgery Today
  • Kozo Miyatani
  • ,
  • Hiroaki Saito
  • ,
  • Yusuke Kono
  • ,
  • Yuki Murakami
  • ,
  • Hirohiko Kuroda
  • ,
  • Tomoyuki Matsunaga
  • ,
  • Yoji Fukumoto
  • ,
  • Tomohiro Osaki
  • ,
  • Keigo Ashida
  • ,
  • Yoshiyuki Fujiwara

48
3
開始ページ
300
終了ページ
307
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1007/s00595-017-1587-6
出版者・発行元
Springer Tokyo

Purpose: The neutrophil–lymphocyte ratio (NLR) is a biochemical marker of the systemic inflammatory response and has been associated with prognosis for various types of cancer. This retrospective study investigates the relationship between the pre- and postoperative NLR and the prognosis of gastric cancer patients. Methods: The subjects were 280 patients who underwent curative surgery for histopathologically diagnosed gastric adenocarcinoma. Results: The preoperative NLR was significantly correlated with tumor size, tumor depth, lymphatic invasion, venous invasion, and disease stage. In contrast, there was no correlation between the postoperative NLR and the various clinicopathological variables. Prognosis was significantly worse for patients with a high preoperative NLR than for those with a low preoperative NLR. Prognosis was also significantly worse for patients with a high postoperative NLR than for those with a low postoperative NLR. Furthermore, the prognosis was worse for gastric cancer patients whose pre- and postoperative NLRs were both high. Multivariate analysis indicated that a high pre- and postoperative NLR was an independent prognostic indicator. Conclusions: The combination of pre- and postoperative NLRs appears to be useful for predicting the prognosis of gastric cancer patients.

リンク情報
DOI
https://doi.org/10.1007/s00595-017-1587-6
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/28916967
ID情報
  • DOI : 10.1007/s00595-017-1587-6
  • ISSN : 1436-2813
  • ISSN : 0941-1291
  • PubMed ID : 28916967
  • SCOPUS ID : 85029501709

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