論文

査読有り
2017年6月

Decreased Serum Concentration of Total IgG Is Related to Tumor Progression in Gastric Cancer Patients

YONAGO ACTA MEDICA
  • Hiroaki Saito
  • ,
  • Kozo Miyatani
  • ,
  • Yusuke Kono
  • ,
  • Yuki Murakami
  • ,
  • Hirohiko Kuroda
  • ,
  • Tomoyuki Matsunaga
  • ,
  • Yoji Fukumoto
  • ,
  • Shuichi Takano
  • ,
  • Tomohiro Osaki
  • ,
  • Yoshiyuki Fujiwara

60
2
開始ページ
119
終了ページ
125
記述言語
英語
掲載種別
研究論文(学術雑誌)
出版者・発行元
TOTTORI UNIV, FACULTY MEDICINE

Background There is accumulating evidence that shows cell-mediated immunity regulated by T cells is impaired in cancer patients. Unfortunately, the mechanisms by which B cells participate in tumor immunity are only partially understood.
Methods The serum concentration of Immunoglobulin G (IgG) was measured by Enzyme-Linked Immuno-Sorbent Assay (ELISA) in patients with gastric cancer. Immunohistochemistry was also performed using the anti-cluster of differentiation (CD) 134 antibody to evaluate the number of plasma cells in the tumor tissue.
Results The total serum IgG concentration was significantly lower in patients with lymph node metastasis compared with patients without metastasis. The serum concentration of total IgG at stage III/IV was significantly lower compared with tumors classified as stage I/II. A decreased serum concentration of total IgG and IgG1 was significantly related to a poor prognosis for gastric cancer patients. Furthermore, multivariate analysis indicated that the serum concentration of IgG and lymph node metastasis were independent prognostic indicators for poorer survival. The number of plasma cells was significantly lower in gastric cancer tissue compared with non-cancerous gastric mucosa.
Conclusion A decreased serum concentration of IgG was closely related to poor prognosis, indicating the possibility that impaired antibody-mediated immunity is associated with tumor progression in patients with gastric cancer.

Web of Science ® 被引用回数 : 8

リンク情報
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/28701895
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000408137900008&DestApp=WOS_CPL
ID情報
  • ISSN : 0513-5710
  • PubMed ID : 28701895
  • Web of Science ID : WOS:000408137900008

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