論文

査読有り
2019年4月10日

Assessment of Coronary Flow Velocity Reserve in the Left Main Trunk Using Phase-contrast MR Imaging at 3T: Comparison with 15O-labeled Water Positron Emission Tomography.

Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine
  • Yasuka Kikuchi
  • ,
  • Masanao Naya
  • ,
  • Noriko Oyama-Manabe
  • ,
  • Osamu Manabe
  • ,
  • Hiroyuki Sugimori
  • ,
  • Kohsuke Kudo
  • ,
  • Fumi Kato
  • ,
  • Tadao Aikawa
  • ,
  • Hiroyuki Tsutsui
  • ,
  • Nagara Tamaki
  • ,
  • Hiroki Shirato

18
2
開始ページ
134
終了ページ
141
記述言語
英語
掲載種別
DOI
10.2463/mrms.mp.2018-0003

PURPOSE: The aim of this study was to verify coronary flow velocity reserve (CFVR) on the left main trunk (LMT) in comparison with myocardial flow reserve (MFR) by 15O-labeled water positron emission tomography (PET) (MFR-PET) in both the healthy adults and the patients with coronary artery disease (CAD), and to evaluate the feasibility of CFVR to detect CAD. METHODS: Eighteen healthy adults and 13 patients with CAD were evaluated. CFVR in LMT was estimated by 3T magnetic resonance imaging (MRI) with phase contrast technique. MFR-PET in the LMT territory including anterior descending artery and circumflex artery was calculated as the ratio of myocardial blood flow (MBF)-PET at stress to MBF-PET at rest. RESULTS: There was a significant positive relationship between CFVR and MFR-PET (R = 0.45, P < 0.0001). Inter-observer calculations of CFVR showed good correlation (R2 = 0.93, P < 0.0001). The CFVR in patients with CAD was significantly lower than that in healthy adults (1.90 ± 0.61 vs. 2.77 ± 1.03, respectively, P = 0.01), which were similar to the results of MFR-PET (2.23 ± 0.84 vs. 3.96 ± 1.04, respectively, P < 0.0001). For the detection of patients with CAD, the area under the curve was 0.78 (P = 0.01). The sensitivity was 0.77 and specificity was 0.72 when a cut-off of 2.15 was used. CONCLUSION: CFVR by 3T was validated with MFR-PET. CFVR could detect the patients with CAD. This method is a simple and reliable index without radiation or contrast material.

リンク情報
DOI
https://doi.org/10.2463/mrms.mp.2018-0003
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/30047496
PubMed Central
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6460128