Makoto Furutachi

Profile Information

Affiliation: Associate Professor, Faculty of Pharmaceutical Sciences, Fukuoka University

Degree: Ph.D.(The University of Tokyo)

Researcher number: 30759931
ORCID iD: https://orcid.org/0000-0002-2790-4400
J-GLOBAL ID: 201501066486494383
researchmap Member ID: 7000011684

External link: https://www.furutachi.com

Research History

Apr, 2024 - Present

Associate Professor at Faculty of Pharmaceutical Sciences, Fukuoka University
Apr, 2019 - Mar, 2024

Lecturer at Faculty of Pharmaceutical Sciences, Fukuoka University
Apr, 2015 - Mar, 2019

Assistant Professor at Faculty of Pharmaceutical Sciences, Fukuoka University (Prof. Kunihiro Sumoto)
Apr, 2013 - Mar, 2015

Postdoctoral Research Fellow at Institute of Microbial Chemistry, Tokyo (Prof. Masakatsu Shibasaki)
Apr, 2011 - Mar, 2013

Research Fellow of the Japan Society for the Promotion of Sciences (DC2)
Apr, 2010 - Mar, 2013

Graduate School of Pharmaceutical Sciences, The University of Tokyo (Prof. Motomu Kanai)
Apr, 2008 - Mar, 2010

Graduate School of Pharmaceutical Sciences, The University of Tokyo (Prof. Masakatsu Shibasaki)
Apr, 2004 - Mar, 2008

Faculty of Pharmaceutical Sciences, Fukuoka University (Prof. Junei Kinjo)
Apr, 2001 - Mar, 2004

Saga Prefectural Karatsu Higashi High School

Committee Memberships

Jul, 2024 - Present

プログラム委員, 日本薬学会第145年会
Jul, 2024 - Present

委員, 薬学共用試験センターシステム検討委員会
Apr, 2021 - Mar, 2022

幹事, 日本薬学会九州山口支部幹事会

Papers

Bioactivity of Boronic Acid Derivative Homodimers

Ota K., Zhou J.-R., Yokomizo K., Kozako T., Honda S., Kashige N., Furutachi M., Sumoto K.,

Results in Chemistry, 4, 100559 (2022)., 4 100559-100559, Oct 5, 2022 Peer-reviewedCorresponding author
Antiviral Activity of Some C3-Symmetrical N-Methyl Benzylamine-Substituted 1,3,5-Triazines and Related Compounds

Shimomura S., Yokomizo K., Zhou J.-R., Mibu N., Furutachi M., Sumoto K.,

Heterocycles, 104, 1845-1853 (2022)., 104(10) 1845-1845, Aug 17, 2022 Peer-reviewed
Hybrid Linker Mode C2-Symmetrical 1,3,5-Triazine Derivatives and Their Biological Evaluation

Shimomura S., Yokomizo K., Zhou J.-R., Ota K., Mibu N., Furutachi M., Sumoto K.,

Heterocycles, 102, 2379-2390 (2021)., Oct 12, 2021 Peer-reviewed
Some New C3- and Cs-Symmetrical Trialkylamino- Substituted 1,3,5-Triazines and Their Biological Evaluation

Shimomura S., Inoue Y., Kawano Y., Fujita Y., Yamada K., Matsumoto Y., Yokomizo K., Zhou J.-R., Ota K., Mibu N., Furutachi M., Sumoto K.,

Heterocycles, 100, 1657-1665 (2020)., 100(10) 1657-1657, Aug 12, 2020 Peer-reviewed
Some Hybrid Linker Mode C2-Symmetrical 1,3,5-Triazine Derivatives and Their Biological Evaluation

Mibu N., Furutachi M., Inoue Y., Fujita Y., Matsumoto Y., Kawano Y., Tomonaga S., Matsuyama J., Yamada K., Sato R., Yokomizo K., Zhou J.-R., Shimomura S., Ota K., Sumoto K.,

Heterocycles, 98, 1580-1588 (2019)., 98(11) 1580-1580, Nov 26, 2019 Peer-reviewed
Anti-proliferative Activities of Some Bivalent Symmetrical 5-Substituted Hydantoin Derivatives towards Human Brain Glioma U251 Cells (U251) and Human Carcinoma Cells (KB3-1)

Furutachi M., Ota K., Fujisaki F., Ikeda R., Yoshikawa N., Yokota T., Takeda Y., Yokomizo K., Zhou J.-R., Kashige N., Miake F., Sumoto K.,

Biol. Pharm. Bull., 42, 1953-1956 (2019)., 42(11) 1953-1956, Nov 1, 2019 Peer-reviewedLead author
Anti-proliferative Activities towards Human Brain Glioma U251 Cells and Human Carcinoma Cells (KB3-1) of Some Twin-Drug Type Bivalent C2-Symmetrical Phenylboronic Acid Derivatives

Furutachi M., Gondo T., Ikeda R., Yoshikawa N., Yokota T., Takeda Y., Yokomizo K., Zhou J.-R., Kashige N., Miake F., Sumoto K.,

Biol. Pharm. Bull., 42, 833-836 (2019)., May 1, 2019 Peer-reviewedLead author
Preparation of Some Novel Trisubstituted 1,3,5-Triazines and Hybrid Linker Mode 1,3,5-Triazine Derivatives and Their Biological Evaluation

Mibu N., Yokomizo K., Yamada K., Matsuyama J., Tomonaga S., Sakai I., Sato R., Kawano Y., Matsumoto Y., Fujita Y., Inoue Y., Iida M., Hashiguchi K., Zhou J.-R., Furutachi M., Sumoto K.,

Heterocycles, 98, 489-508 (2019)., 98(4) 489-489, Mar 25, 2019 Peer-reviewed
Preparation of Novel Bivalent Linker Mode Phenylboronic Acid Derivatives and Their Biological Evaluation

Furutachi M., Matsumoto A., Tamenaga T., Sugita A., Kuroiwa M., Yokomizo K., Zhou J.-R., Kashige N., Miake F., Sumoto K.,

Heterocycles, 96, 1088-1100 (2018)., 96(6) 1088-1088, May 15, 2018 Peer-reviewedLead author
Novel Trivalent C3-Symmetrical Phenylboronic Acid Pinacol Esters and Their Biological Evaluation

Furutachi M., Fuchigami S., Ako K., Goto S., Gondo T., Takuse M., Yoshida M., Yokomizo K., Zhou J.-R., Matsunaga A., Hiraga N., Kashige N., Miake F., Sumoto K.,

Heterocycles, 96, 144-151 (2018)., 96(1) 144-144, Dec 13, 2017 Peer-reviewedLead author
Novel C2-Symmetrical Phenylboronic Acid Pinacol Esters with a Few Types of Linkers and Their Biological Activities

Furutachi M., Gondo T., Goto S., Fuchigami S., Ako K., Oowada Y., Yokomizo K., Zhou J.-R., Ishizaki T., Koga T., Kashige N., Miake F., Sumoto K.,

Heterocycles, 94, 1748-1758 (2017)., 94(9) 1748-1748, Jul 14, 2017 Peer-reviewedLead author
Novel Trivalent C3-Symmetrical Phenylboronic Acid Pinacol Esters

Furutachi M., Fuchigami S., Gondo T., Goto S., Ako K., Sumoto K.,

Org. Prep. Proced. Int., 49, 287-292 (2017)., 49(3) 287-292, Jun 1, 2017 Peer-reviewedLead author
Unique Physicochemical and Catalytic Properties Dictated by the B3NO2 Ring System

Noda H., Furutachi M., Asada Y., Shibasaki M., Kumagai N.,

Nat. Chem., 9, 571-577 (2017). Highlighted in C&EN (January 30th, 2017), 毎日新聞(2017年1月31日), 日経産業新聞(2017年1月31日), Synform, 10, A165-A168 (2017). B3NO2 was nominated for "Molecules of the year (C&EN)", 9(6) 571-577, Jan 30, 2017 Peer-reviewed
Catalytic Asymmetric Synthesis of the C1-C15 Segment of Spirastrellolide A

Sahara Y., Cui J., Furutachi M., Chen J., Watanabe T., Shibasaki M.,

Synthesis, 49, 69-75 (2017)., 49(01) 69-75, Sep 23, 2016 Peer-reviewed
Preparation and Biological Activity of Novel Twin-drug Type C2-Symmetrical Cyclic Phenylboronic Acid Derivatives

Furutachi M., Ejima A., Tsuru R., Goto S., Gondo T., Ako K., Fuchigami S., Fujii S., Okumura A., Tozuka A., Yokomizo K., Zhou J.-R., Inao H., Ono Y., Kashige N., Miake F., Sumoto K.,

Heterocycles, 95, 517-524 (2017)., 95(1) 517-517, Jul 13, 2016 Peer-reviewedLead author
Synthesis and Antibacterial Evaluation of Some New 5-Substituted Hydantoins and Novel Twin-drug Type Derivatives

Furutachi M., Fujisaki F., Tsuru R., Ejima A., Gondo T., Goto S., Ito M., Nakamura M., Aki H., Kashige N., Miake F., Sumoto K.,

Heterocycles, 92, 1111-1120 (2016)., 92(6) 1111-1111, Apr 5, 2016 Peer-reviewedLead author
Novel Twin-drug Type C2-Symmetrical Phenylboronic Acid Pinacol Esters

Furutachi M., Ejima A., Tsuru R., Goto S., Gondo T., Ako K., Fujii S., Okumura A., Tozuka A., Yokomizo K., Zhou J.-R., Inao H., Ono Y., Kashige N., Miake F., Sumoto K.,

Heterocycles, 92, 925-935 (2016)., 92(5) 925-925, Mar 15, 2016 Peer-reviewedLead author
Preparation and Antibacterial Evaluation of Some Symmetrical Twin-drug Type Bivalent Molecules

Fujisaki F., Furutachi M., Fujiwara R., Okabe M., Aki H., Kashige N., Miake F., Sumoto K.,

Heterocycles, 91, 1668-1677 (2015)., 91(8) 1668-1668, Jul 6, 2015 Peer-reviewed
Chromatography-free Synthesis of Corey’s Intermediate for Tamiflu

Furutachi M., Kumagai N., Watanabe T., Shibasaki M.,

Tetrahedron, 70, 9113-9117 (2014)., 70(47) 9113-9117, Oct 2, 2014 Peer-reviewedLead author
An Enantioselective Synthesis of Voriconazole

Tamura K., Furutachi M., Kumagai N., Shibasaki M.,

J. Org. Chem., 78, 11396-11403 (2013)., 78(22) 11396-11403, Oct 8, 2013 Peer-reviewed

Presentations

機械学習を用いた医薬品候補化合物の探索と合成

日本薬学会第145年会(福岡), Mar, 2025
一置換、二置換および三置換アミノピリジンとベンズアルデヒドとの反応におけるアミノピリジンの位置選択性

日本薬学会第145年会(福岡), Mar, 2025
機械学習を用いた医薬品候補化合物の探索と合成

第41回メディシナルケミストリーシンポジウム(京都), Nov, 2024
神経伝達物質を認識する平面性包接化合物の合成

日本薬学会第144年会(横浜), Mar, 2024
KDEL受容体を阻害する低分子医薬品候補化合物の合成

日本薬学会第144年会(横浜), Mar, 2024
熱力学的安定性を減弱したボロン酸エステルホモ二量体の合成

日本薬学会第144年会(横浜), Mar, 2024
Organic Boron Homodimer for Drug Candidate Compounds

28th French-Japanese Symposium on Medicinal & Fine Chemistry (FJS 2023) (Nice, France), Oct, 2023
薬学生の視点で感じた在宅医療と地域医療の現状〜鹿児島での長期実務実習を通して〜

第16回日本在宅薬学会学術大会日在薬の夏フェス'23(神戸), Jul, 2023
神経伝達物質を認識する平面性包接化合物の合成

日本薬学会第143年会(札幌), Mar, 2023
C2対称性ビスイソキノリン誘導体の合成

日本薬学会第143年会(札幌), Mar, 2023
水素結合供与能を減弱したボロン酸ホモ二量体の合成と生物活性評価

日本薬学会第142年会(名古屋), Mar, 2022
三環性ヘテロ環化合物の合成

日本薬学会第142年会(名古屋), Mar, 2022
DNAに干渉する新規低分子化合物の合成

日本薬学会第142年会(名古屋), Mar, 2022
イミダゾピリジン誘導体および新規七環性化合物の合成

日本薬学会第142年会(名古屋), Mar, 2022
遷移金属触媒反応を用いたベンゼン環伸長反応の開発

日本薬学会第142年会(名古屋), Mar, 2022
新規4置換炭素化合物の合成

日本薬学会第142年会(名古屋), Mar, 2022
鈴木-宮浦クロスカップリング反応による連続4級炭素構築法の開発

日本薬学会第142年会(名古屋), Mar, 2022
C2対称性ビスイソキノリン誘導体の合成

日本薬学会第142年会(名古屋), Mar, 2022
Bioactivity of Boronic Acid Derivative Homodimers

13th AFMC International Medicinal Chemistry Symposium (AIMECS 2021) (Online Symposium), Nov, 2021
C3対称性トリアジン誘導体の合成

日本薬学会第141年会(広島), Mar, 2021

Research Projects

Development of a novel cancer therapy utilizing the intracellular and extracellular cycle of the chaperone complex controlled by mutant KRAS

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2024 - Mar, 2027
Development of a cancer therapy targeting the pathological protein refolding mechanism activated by mutant KRAS

Japan Science and Technology Agency (JST), Sep, 2024 - Mar, 2026
Catalytic control of chemoselectivity by the functional group targeted catalyst

Grants-in-Aid for Scientific Research, Grant-in-Aid for Transformative Research Areas (A), Japan Society for the Promotion of Science, Apr, 2024 - Mar, 2026
研究助成寄附金

研究助成寄附金, 日産化学工業(株), Apr, 2022 - Mar, 2026

古舘信
Optimization of seed compound toward Dravet syndrome and obtaining POC in animal model

Japan Agency for Medical Research and Development (AMED), Apr, 2023 - Mar, 2024
Synthesis of Axial Chiral Ligand

Fukuoka University, Apr, 2022 - Mar, 2024
Creation of Organic Boron Homodimer for Drug Candidate Compounds

Fukuoka University, Apr, 2022 - Mar, 2024

Furutachi Makoto
体に優しい次世代の分子標的薬の開発：癌細胞が過酷な環境でも生き残るしくみを抑える

PARKS起業活動支援プログラム GAPファンド, JST大学発新産業創出プログラム（START）大学・エコシステム推進型, Oct, 2022 - Mar, 2023

角田俊之, 白澤専二, 吉田和真, 末永正彦, 大嶋孝志, 矢崎亮, 本多進, 古舘信, 大田香
KDEL受容体を制御する低毒性抗腫瘍性低分子化合物の開発

福岡バイオ産業創出事業に係る可能性試験事業, 久留米リサーチパーク, Jun, 2022 - Mar, 2023

角田俊之, 古舘信, 大田香
Synthesis of Axial Chiral Ligand

Fukuoka University, Apr, 2021 - Mar, 2022

Yoshinobu Tagawa, Furutachi Makoto
Sugar chain targeting symmetrical boronic acid derivatives

Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B), Grant-in-Aid for Young Scientists (B), Japan Society for the Promotion of Science, Apr, 2017 - Mar, 2019

Furutachi Makoto

Industrial Property Rights

特願2016-028596 触媒、アミド結合の形成方法、及びアミド化合物の製造方法

熊谷直哉, 野田秀俊, 古舘信, 朝田康子, 柴﨑正勝
特願2012-266285 化合物、及びその製造方法、並びにリン酸オセルタミビルの製造方法

柴﨑正勝, 渡邊匠, 熊谷直哉, 山次健三, アラギリカリヤムーティー, 古舘信
特願2009-047245 光学活性ジマンガン錯体

柴﨑正勝, 松永茂樹, 加藤祐子, 陳志華, 古舘信

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