1997年9月
Preparation of peptide thioesters using Fmoc-solid-phase peptide synthesis and its application to the construction of a template-assembled synthetic protein (TASP)
TETRAHEDRON LETTERS
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- 巻
- 38
- 号
- 35
- 開始ページ
- 6237
- 終了ページ
- 6240
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1016/S0040-4039(97)01434-2
- 出版者・発行元
- PERGAMON-ELSEVIER SCIENCE LTD
Preparation of peptide thioesters was conducted through peptide chain construction with Fmoc-solid-phase peptide synthesis on a 2-chlorotrityl resin followed by coupling with HS-(CH2)(2)-COOEt and deprotection with 95% aqueous CF3COOH. The peptide thioester corresponding to a transmembrane segment of he calcium channel (S4 in repeat IV) thus obtained was introduced onto a peptide template to give an artificial four-helix-bundle protein. (C) 1997 Elsevier Science Ltd.
- リンク情報
- ID情報
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- DOI : 10.1016/S0040-4039(97)01434-2
- ISSN : 0040-4039
- Web of Science ID : WOS:A1997XT72400034