論文

査読有り
2012年4月

Chemokine Signaling Directs Trunk Lymphatic Network Formation along the Preexisting Blood Vasculature

DEVELOPMENTAL CELL
  • Young Ryun Cha
  • ,
  • Misato Fujita
  • ,
  • Matthew Butler
  • ,
  • Sumio Isogai
  • ,
  • Eva Kochhan
  • ,
  • Arndt F. Siekmann
  • ,
  • Brant M. Weinstein

22
4
開始ページ
824
終了ページ
836
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1016/j.devcel.2012.01.011
出版者・発行元
CELL PRESS

The lymphatic system is crucial for fluid homeostasis, immune responses, and numerous pathological processes. However, the molecular mechanisms responsible for establishing the anatomical form of the lymphatic vascular network remain largely unknown. Here, we show that chemokine signaling provides critical guidance cues directing early trunk lymphatic network assembly and patterning. The chemokine receptors Cxcr4a and Cxcr4b are expressed in lymphatic endothelium, whereas chemokine ligands Cxcl12a and Cxcl12b are expressed in adjacent tissues along which the developing lymphatics align. Loss- and gain-of-function studies in zebrafish demonstrate that chemokine signaling orchestrates the stepwise assembly of the trunk lymphatic network. In addition to providing evidence for a lymphatic vascular guidance mechanism, these results also suggest a molecular basis for the anatomical coalignment of lymphatic and blood vessels.

Web of Science ® 被引用回数 : 72

リンク情報
DOI
https://doi.org/10.1016/j.devcel.2012.01.011
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000303099400016&DestApp=WOS_CPL

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