論文

査読有り
2011年5月

Assembly and patterning of the vascular network of the vertebrate hindbrain

DEVELOPMENT
  • Misato Fujita
  • ,
  • Young R. Cha
  • ,
  • Van N. Pham
  • ,
  • Atsuko Sakurai
  • ,
  • Beth L. Roman
  • ,
  • J. Silvio Gutkind
  • ,
  • Brant M. Weinstein

138
9
開始ページ
1705
終了ページ
1715
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1242/dev.058776
出版者・発行元
COMPANY OF BIOLOGISTS LTD

The cranial vasculature is essential for the survival and development of the central nervous system and is important in stroke and other brain pathologies. Cranial vessels form in a reproducible and evolutionarily conserved manner, but the process by which these vessels assemble and acquire their stereotypic patterning remains unclear. Here, we examine the stepwise assembly and patterning of the vascular network of the zebrafish hindbrain. The major artery supplying the hindbrain, the basilar artery, runs along the ventral keel of the hindbrain in all vertebrates. We show that this artery forms by a novel process of medial sprouting and migration of endothelial cells from a bilateral pair of primitive veins, the primordial hindbrain channels. Subsequently, a second wave of dorsal sprouting from the primordial hindbrain channels gives rise to angiogenic central arteries that penetrate into and innervate the hindbrain. The chemokine receptor cxcr4a is expressed in migrating endothelial cells of the primordial hindbrain channels, whereas its ligand cxcl12b is expressed in the hindbrain neural keel immediately adjacent to the assembling basilar artery. Knockdown of either cxcl12b or cxcr4a results in defects in basilar artery formation, showing that the assembly and patterning of this crucial artery depends on chemokine signaling.

Web of Science ® 被引用回数 : 56

リンク情報
DOI
https://doi.org/10.1242/dev.058776
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000289406900006&DestApp=WOS_CPL

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