論文

国際誌
2022年2月18日

Cathodic- and anodic-pulses can alternately activate different sub-populations of neurons during sustained high-frequency stimulation of axons in rat hippocampus.

Journal of neural engineering
  • Zhouyan Feng
  • ,
  • Lvpiao Zheng
  • ,
  • Yue Yuan
  • ,
  • Gangsheng Yang
  • ,
  • Yifan Hu
  • ,
  • Chuchu Lu
  • ,
  • Zhaoxiang Wang

19
1
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1088/1741-2552/ac518c

Objective.Charge-balanced biphasic-pulses are commonly used in neural stimulations to prevent possible damages caused by charge accumulations. The lagging anodic-phases of biphasic-pulses may decrease the activation efficiency of stimulations by counteracting the depolarization effect of the leading cathodic-phases. However, a monophasic anodic-pulse alone can itself activate neurons by depolarizing neuronal membrane through a mechanism of virtual cathode. This study aimed to verify the hypothesis that the anodic-phases/pulses in charge-balanced stimulations could play an activation role during sustained high-frequency stimulations (HFSs).Approach.Two types of antidromic HFS (A-HFS) were applied on the alveus of hippocampal CA1 region of anesthetized rats: monophasic-pulse A-HFS of alternate opposite pulses and biphasic-pulse A-HFS with the same frequency of 100 or 200 Hz. The antidromically-evoked population spike was used as a biomarker to evaluate the activation effects of A-HFS pulses.Main results.Despite a significant difference in the initial abilities of anodic- and cathodic-pulses to activate neurons, an anodic-pulse was able to induce similar amount of neuronal firing as a cathodic-pulse during sustained monophasic-pulse A-HFS. Additionally, the amount of neuronal firing induced by the monophasic-pulse A-HFS was similar to that induced by the biphasic-pulse A-HFS consuming a double amount of electrical energy. Furthermore, the alternate cathodic- and anodic-pulses respectively activated different sub-populations of neurons during steady A-HFS.Significance.The anodic-phases/pulses in charge-balanced HFS at axons can play an activation role in addition to a role of charge balance. The study provides important information for designing charge-balanced stimulations and reveals new mechanisms of neural stimulations.

リンク情報
DOI
https://doi.org/10.1088/1741-2552/ac518c
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/35114653
ID情報
  • DOI : 10.1088/1741-2552/ac518c
  • PubMed ID : 35114653

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