論文

国際誌
2021年12月25日

[Design and application of neural electrical stimulation system with time-varying parameters].

Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi
  • Gangsheng Yang
  • ,
  • Zhouyan Feng
  • ,
  • Lupiao Zheng
  • ,
  • Zhaoxiang Wang

38
6
開始ページ
1144
終了ページ
1153
記述言語
中国語
掲載種別
研究論文(学術雑誌)
DOI
10.7507/1001-5515.202102028

Currently, commercial devices for electrical neural stimulations can only provide fixed stimulation paradigms with preset constant parameters, while the development of new stimulation paradigms with time-varying parameters has emerged as one of the important research directions for expanding clinical applications. To facilitate the performance of electrical stimulation paradigms with time-varying parameters in animal experiments, the present study developed a well-integrated stimulation system to output various pulse sequences by designing a LabVIEW software to control a general data acquisition card and an electrical stimulus isolator. The system was able to generate pulse sequences with inter-pulse-intervals (IPI) randomly varying in real time with specific distributions such as uniform distribution, normal distribution, gamma distribution and Poisson distribution. It was also able to generate pulse sequences with arbitrary time-varying IPIs. In addition, the pulse parameters, including pulse amplitude, pulse width, interphase delay of biphasic pulse and duration of pulse sequence, were adjustable. The results of performance tests of the stimulation system showed that the errors of the parameters of pulse sequences output by the system were all less than 1%. By utilizing the stimulation system, pulse sequences with IPI randomly varying in the range of 5~10 ms were generated and applied in rat hippocampal regions for animal experiments. The experimental results showed that, even with a same mean pulse frequency of ~130 Hz, for neuronal populations, the excitatory effect of stimulations with randomly varying IPIs was significantly greater than the effect of stimulations with fixed IPIs. In conclusion, the stimulation system designed here may provide a useful tool for the researches and the development of new paradigms of neural electrical stimulations.

リンク情報
DOI
https://doi.org/10.7507/1001-5515.202102028
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/34970898
PubMed Central
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9927115
ID情報
  • DOI : 10.7507/1001-5515.202102028
  • PubMed ID : 34970898
  • PubMed Central 記事ID : PMC9927115

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