論文

査読有り 国際誌
2017年4月7日

Engrams and circuits crucial for systems consolidation of a memory.

Science (New York, N.Y.)
  • Takashi Kitamura
  • ,
  • Sachie K Ogawa
  • ,
  • Dheeraj S Roy
  • ,
  • Teruhiro Okuyama
  • ,
  • Mark D Morrissey
  • ,
  • Lillian M Smith
  • ,
  • Roger L Redondo
  • ,
  • Susumu Tonegawa

356
6333
開始ページ
73
終了ページ
78
記述言語
英語
掲載種別
DOI
10.1126/science.aam6808

Episodic memories initially require rapid synaptic plasticity within the hippocampus for their formation and are gradually consolidated in neocortical networks for permanent storage. However, the engrams and circuits that support neocortical memory consolidation have thus far been unknown. We found that neocortical prefrontal memory engram cells, which are critical for remote contextual fear memory, were rapidly generated during initial learning through inputs from both the hippocampal-entorhinal cortex network and the basolateral amygdala. After their generation, the prefrontal engram cells, with support from hippocampal memory engram cells, became functionally mature with time. Whereas hippocampal engram cells gradually became silent with time, engram cells in the basolateral amygdala, which were necessary for fear memory, were maintained. Our data provide new insights into the functional reorganization of engrams and circuits underlying systems consolidation of memory.

リンク情報
DOI
https://doi.org/10.1126/science.aam6808
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/28386011
PubMed Central
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5493329
ID情報
  • DOI : 10.1126/science.aam6808
  • PubMed ID : 28386011
  • PubMed Central 記事ID : PMC5493329

エクスポート
BibTeX RIS