2021年4月19日
Reconstruction of Carbon Bond Frameworks via Oxapalladacycle Promoted by Synergistic Effect of Palladium Catalyst and Triethylborane
Synthesis
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- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1055/a-1485-5781
- 出版者・発行元
- Georg Thieme Verlag KG
Pd-catalyzed β-carbon elimination of 3-hydroxy-4-pentenoic acid derivatives promoted by triethylborane proceeded to form conjugated dienes via a decarboxylation process. The formed conjugated dienes underwent the Prins reaction with aldehydes in situ to afford conjugated homoallylic alcohols. These sequential transformations enabled conversion of a diastereomeric mixture of 3-hydroxy-4-pentenoic acids, which were readily prepared from the simple crossed aldol reaction of esters and α,β-unsaturated aldehydes, to 3,5-hexadienyl alcohols with high regio- and stereoselectivities in a single manipulation.
- リンク情報
- ID情報
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- DOI : 10.1055/a-1485-5781
- ISSN : 0039-7881
- eISSN : 1437-210X