Hassan Ghmkin (Ghmkin Hassan) - マイポータル

基本情報

所属: 大学院医系科学研究科広島大学助教

研究者番号: 10943558
ORCID iD: https://orcid.org/0000-0002-2725-7899
J-GLOBAL ID: 202201008312668787
researchmap会員ID: R000032363

受賞

研究科長賞, 岡山大学大学院ヘルスシステム統合科学研究科

論文

Cancer stem cells as the source of tumor associated myoepithelial cells in the tumor microenvironment developing ductal carcinoma in situ.

Said M Afify, Ghmkin Hassan, Maram H Zahra, Hend M Nawara, Hagar A Abu Quora, Amira Osman, Hager Mansour, Kazuki Kumon, Akimasa Seno, Ling Chen …

Biomaterials 301 122249-122249 2023年10月
GSK-3α/β and MEK inhibitors assist the microenvironment of tumor initiation.

Ghmkin Hassan, Said M Afify, Maram H Zahra, Hend M Nawara, Kazuki Kumon, Yoshiaki Iwasaki, David S Salomon, Akimasa Seno, Masaharu Seno

Cytotechnology 75(3) 243-253 2023年6月
Cancer stem cells induced by chronic stimulation with prostaglandin E2 exhibited constitutively activated PI3K axis.

Hideki Minematsu, Said M Afify, Yuki Sugihara, Ghmkin Hassan, Maram H Zahra, Akimasa Seno, Masaki Adachi, Masaharu Seno

Scientific reports 12(1) 15628-15628 2022年9月17日
BMP and activin membrane-bound inhibitor regulate connective tissue growth factor controlling mesothelioma cell proliferation.

Nguyen Truong Duc Hoang, Ghmkin Hassan, Tomoya Suehiro, Yuichi Mine, Tohru Matsuki, Makiko Fujii

BMC cancer 22(1) 984-984 2022年9月15日
A comparative study of metastatic potentials of three different cancer stem cell models

Hager Mansour, Said M. Afify, Ghmkin Hassan, Hagar A. Abu Quora, Hend M. Nawara, Maram H. Zahra, Juan Du, Sadia Monzur, Toshiaki Ohara, Akimasa Seno …

Advances in Cancer Biology - Metastasis 100062-100062 2022年8月
Optimization of production and characterization of a recombinant soluble human Cripto-1 protein inhibiting self-renewal of cancer stem cells.

Said M Afify, Ghmkin Hassan, Hend M Nawara, Maram H Zahra, Yanning Xu, Md Jahangir Alam, Koichi Saitoh, Hager Mansour, Hagar A Abu Quora, Mona Sheta …

Journal of cellular biochemistry 2022年5月16日
Diphenyleneiodonium efficiently inhibits the characteristics of a cancer stem cell model derived from induced pluripotent stem cells.

Sadia Monzur, Ghmkin Hassan, Said M Afify, Kazuki Kumon, Hager Mansour, Hend M Nawara, Mona Sheta, Hagar A Abu Quora, Maram H Zahra, Yanning Xu …

Cell biochemistry and function 40(3) 310-320 2022年4月
Cancer-inducing niche: the force of chronic inflammation.

Said M Afify, Ghmkin Hassan, Akimasa Seno, Masaharu Seno

British journal of cancer 2022年3月15日
The significance of ErbB2/3 in the conversion of induced pluripotent stem cells into cancer stem cells.

Ghmkin Hassan, Maram H Zahra, Akimasa Seno, Masaharu Seno

Scientific reports 12(1) 2711-2711 2022年2月17日
Different pancreatic cancer microenvironments convert iPSCs into cancer stem cells exhibiting distinct plasticity with altered gene expression of metabolic pathways.

Ghmkin Hassan, Toshiaki Ohara, Said M Afify, Kazuki Kumon, Maram H Zahra, Xiaoying Fu, Mohamad Al Kadi, Akimasa Seno, David S Salomon, Masaharu Seno

Journal of experimental & clinical cancer research : CR 41(1) 29-29 2022年1月21日
The efficacy of PI3Kγ and EGFR inhibitors on the suppression of the characteristics of cancer stem cells.

Yanning Xu, Said M Afify, Juan Du, Bingbing Liu, Ghmkin Hassan, Qing Wang, Hanbo Li, Yixin Liu, Xiaoying Fu, Zhengmao Zhu …

Scientific reports 12(1) 347-347 2022年1月10日
Functional and Molecular Characters of Cancer Stem Cells Through Development to Establishment.

Said M Afify, Ghmkin Hassan, Hiroko Ishii, Sadia Monzur, Hend M Nawara, Amira Osman, Hagar A Abu Quora, Mona Sheta, Maram H Zahra, Akimasa Seno …

Advances in experimental medicine and biology 1393 83-101 2022年
Cancer Stem Cells Contribute to Drug Resistance in Multiple Different Ways.

Maram H Zahra, Hend M Nawara, Ghmkin Hassan, Said M Afify, Akimasa Seno, Masaharu Seno

Advances in experimental medicine and biology 1393 125-139 2022年
MEK1/2 is a bottleneck that induces cancer stem cells to activate the PI3K/AKT pathway

Ghmkin Hassan, Said M. Afify, Juan Du, Hend M. Nawara, Mona Sheta, Sadia Monzur, Maram H. Zahra, Hagar A. Abu Quora, Hager Mansour, Samah El-Ghlban …

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 583 49-55 2021年12月
Differentiation of cancer stem cells into erythroblasts in the presence of CoCl2

Kazuki Kumon, Said M. Afify, Ghmkin Hassan, Shunsuke Ueno, Sadia Monzur, Hend M. Nawara, Hagar A. Abu Quora, Mona Sheta, Yanning Xu, Xiaoying Fu …

SCIENTIFIC REPORTS 11(1) 2021年12月
Chronic exposure to FGF2 converts iPSCs into cancer stem cells with an enhanced integrin/focal adhesion/PI3K/AKT axis

Mona Sheta, Ghmkin Hassan, Said M. Afify, Sadia Monzur, Kazuki Kumon, Hagar A. Abu Quora, Mahmoud Farahat, Maram H. Zahra, Xiaoying Fu, Akimasa Seno …

CANCER LETTERS 521 142-154 2021年11月
Metformin suppresses self-renewal and stemness of cancer stem cell models derived from pluripotent stem cells

Maram H. Zahra, Said M. Afify, Ghmkin Hassan, Hend M. Nawara, Kazuki Kumon, Akimasa Seno, Masaharu Seno

CELL BIOCHEMISTRY AND FUNCTION 39(7) 896-907 2021年10月
How can we turn the PI3K/AKT/mTOR pathway down? Insights into inhibition and treatment of cancer

Said M. Afify, Aung Ko Ko Oo, Ghmkin Hassan, Akimasa Seno, Masaharu Seno

EXPERT REVIEW OF ANTICANCER THERAPY 21(6) 605-619 2021年6月
Cripto-1 as a Potential Target of Cancer Stem Cells for Immunotherapy

Hiroko Ishii, Said M. Afify, Ghmkin Hassan, David S. Salomon, Masaharu Seno

CANCERS 13(10) 2021年5月
Paclitaxel-Based Chemotherapy Targeting Cancer Stem Cells from Mono- to Combination Therapy

Hend M. Nawara, Said M. Afify, Ghmkin Hassan, Maram H. Zahra, Akimasa Seno, Masaharu Seno

BIOMEDICINES 9(5) 2021年5月

もっとみる

書籍等出版物

Induced Pluripotent Stem Cells and Human Disease (chapter 24)

Said M Afify, Ghmkin Hassan, Ting Yan, Akimasa Seno, Masaharu Seno (担当:共著)

Humana New York, NY 2022年 (ISBN: 9781071625859)
Stem cells : latest advances (Chapter 13)

Ghmkin Hassan, Said M. Afify, Juan Du, Akimasa Seno, Masaharu Seno (担当:分担執筆)

Springer 2021年 (ISBN: 9783030770518)
iPSC Derived Progenitors, Volume 13 in Advances in Stem Cell Biology (Chapter 12)

Akimasa Seno, Said M.Afify, Ghmkin Hassan, Masaharu Seno (担当:分担執筆)

Elsevier Inc. 2021年 (ISBN: 9780323855457)

講演・口頭発表等

The iPSCs under pancreatic cancer microenvironments convert into cancer stem cells with distinct plasticity and altered gene expression of metabolic pathways

Ghmkin Hassan, Masaharu Seno

The 7th JCA-AACR Special Joint Conference 2022年7月
Mimicking tumor initiation microenvironment in the presence of MEK and GSK-3 inhibitors convert hiPSCs into cancer stem cells.

Ghmkin Hassan, Said M. Afify, Maram H. Zahara, David S, Salomon, Akimasa Seno, Masaharu Seno

日本組織培養学会第93回大会 2021年
MEK and GSK-3 inhibitors enhance the microenvironment of tumor initiation

第80回日本癌学会学術総会 2021年
Cancer stem cells as origin of tumor associated immune cells

Tumor Immunology and Immunotherapy Virtual Special Conference 2020年10月
The conversion of induced pluripotent stem cells into cancer stem cells under pancreatic cancer microenvironment is inhibiting by lapatinib

AACR Virtual Special Conference on Pancreatic Cancer 2020年9月
Cancer stem cells could be responsible for the chimeras of hematopoietic cells in the cancer microenvironment

American Association for Cancer Research (AACR) Annual Meeting 2020年
The role of Erbb2/Erbb3 signal pathway in generation of cancer stem cells

International Society for Stem Cell Research 2020 Virtual Annual Meeting 2020年
Cancer stem cell models converted from induced pluripotent stem cells: new tools for cancer field

Towards knowledge economy: the role of the Syrian researchers in Syria and abroad meeting. 2020年
Inhibition of MEK/ERK pathway and overactivation of PI3K/AKT convert iPS Cells into cancer stem cells in the tumor microenvironment

第43回日本分子生物学会年会 2020年
The Role of ERBB2/ERBB3 Signal Pathway in Generation of Cancer Stem Cells

第79回日本癌学会学術総会 2020年
MAPK cascade inhibition along with increasing PI3K/AKT signaling activation convert iPS Cells into cancer stem cells in the tumor microenvironment

Cell Bio Virtual 2020 - An Online ASCB|EMBO Meeting 2020年
Hematopoietic-like cells derived from cancer stem cells with engraftment potential: a novel concept of hematopoiesis and cancer

第42回日本分子生物学会年会 2019年
The iPSCs derived cancer stem cells: A model to investigate the differentiation potential of breast cancer stem cells to hematopoietic like cells

CiRA 2019 International Symposium 2019年
Hematopoietic Like Cells Derived from Cancer Stem Cells Generated from Mouse Induced Pluripotent Stem Cells

第78回日本癌学会学術総会 2019年

担当経験のある科目(授業)

所属学協会

2020年6月

International Society for Stem Cell Research (ISSCR).
2020年6月

The American Association for Cancer Research (AACR)
2019年7月

日本分子生物学会
2019年7月

日本癌学会

共同研究・競争的資金等の研究課題

Development of Novel Immunotherapy Strategy for Head and Neck Squamous Cell Carcinoma by Stimulating Anticancer Immunity Using Programmed Cell Death Protein Ligand 1 and B7 Homolog 3 Inhibitors

日本学術振興会科学研究費助成事業若手研究 2023年4月 - 2026年3月

HASSAN GHMKIN

学術貢献活動

Signal transduction and targeted therapy Journal

査読
Stem Cells International Journal

査読
Journal of Cellular and Molecular Medicine

査読
Advanced Biology Journal

査読
Frontiers in Oncology Journal

査読
Journal of Translational Medicine

査読
Frontiers in Cell and Developmental Biology journal

査読