May, 2012
Possible Modulation of Process Extension by N-Methyl-D-aspartate Receptor Expressed in Osteocytic MLO-Y4 Cells
JOURNAL OF PHARMACOLOGICAL SCIENCES
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- Volume
- 119
- Number
- 1
- First page
- 112
- Last page
- 116
- Language
- English
- Publishing type
- Research paper (scientific journal)
- DOI
- 10.1254/jphs.12068SC
- Publisher
- JAPANESE PHARMACOLOGICAL SOC
In contrast to osteoblasts, little attention has been paid to expression profiles of different glutamatergic signaling machineries in osteocytes, which are the most abundant cells with a possible role as a mechanical sensor in bone. Here, we show that N-methyl-D-aspartate receptor (NMDAR) is expressed by osteocytic cells in five-weeks-old mouse tibiae in vivo as well as by osteocytic MLO-Y4 cells in vitro. Sustained exposure to the NMDAR antagonist dizocilpine significantly increased the number of cells with processes in cultured MLO-Y4 cells. These results suggest that NMDAR would be expressed by osteocytes with an unidentified role in the process extension.
- Link information
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- DOI
- https://doi.org/10.1254/jphs.12068SC
- CiNii Articles
- http://ci.nii.ac.jp/naid/40019255728
- PubMed
- https://www.ncbi.nlm.nih.gov/pubmed/22641131
- Web of Science
- https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000304490300014&DestApp=WOS_CPL
- ID information
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- DOI : 10.1254/jphs.12068SC
- ISSN : 1347-8613
- CiNii Articles ID : 40019255728
- Pubmed ID : 22641131
- Web of Science ID : WOS:000304490300014