Apr, 2019 - Mar, 2022
The clarification of bone formation and absorption mechanism in the bone marrow microenvironment
Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B) Grant-in-Aid for Scientific Research (B)
- Grant number
- 19H03842
- Japan Grant Number (JGN)
- JP19H03842
- Grant amount
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- (Total)
- 17,550,000 Japanese Yen
- (Direct funding)
- 13,500,000 Japanese Yen
- (Indirect funding)
- 4,050,000 Japanese Yen
BMP-2 has been widely studied for its potent ability to induce osteoblast differentiation and ectopic bone formation, and is already in clinical use worldwide. On the other hand, we have shown that BMP-2 inhibits bone formation in the bone marrow. However, the mechanism by which BMP-2 suppresses bone formation remains unclear. Therefore, we analyzed the detail of BMP-2 induced bone. Single cell RNA-seq analysis revealed that BMP-2-induced bone formed bone marrow with hematopoietic function. These results suggest that BMP-2 has the ability to regenerate bone marrow as an organ, and may suppress bone formation in the bone marrow in order to reserve space for hematopoiesis.
- Link information
- ID information
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- Grant number : 19H03842
- Japan Grant Number (JGN) : JP19H03842