Apr, 2018 - Mar, 2021
Understanding of molecular mechanisms of tooth development using iPS interference and application to tooth regeneration techniques
Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B) Grant-in-Aid for Scientific Research (B)
- Grant number
- 18H02991
- Japan Grant Number (JGN)
- JP18H02991
- Grant amount
-
- (Total)
- 17,550,000 Japanese Yen
- (Direct funding)
- 13,500,000 Japanese Yen
- (Indirect funding)
- 4,050,000 Japanese Yen
Whole-tooth regeneration is ultimate goal in dental field and the goal of this study is to identify the master transcription factors that characterize tooth germ derived epithelial and mesenchymal cells and develop method to generate those cells. First, we analyzed the mouse embryonic tooth germ and human stem cell from the apical papilla (hSCAP) by RNA-Seq and performed iPS interference to identify the potential transcription factors. Finally, candidate transcription factors were overexpressed in human adult dermal fibroblast (hADF), resulting that hADF was induced into the cells similar to tooth germ derived mesenchymal cells.
- Link information
- ID information
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- Grant number : 18H02991
- Japan Grant Number (JGN) : JP18H02991