論文

査読有り
2017年2月

Susceptibility of isogeneic ginbuna Carassius auratus langsdorfii Temminck et Schlegel to cyprinid herpesvirus-2 (CyHV-2) as a model species

JOURNAL OF FISH DISEASES
  • A. Nanjo
  • ,
  • T. Shibata
  • ,
  • M. Saito
  • ,
  • K. Yoshii
  • ,
  • M. Tanaka
  • ,
  • T. Nakanishi
  • ,
  • H. Fukuda
  • ,
  • T. Sakamoto
  • ,
  • G. Kato
  • ,
  • M. Sano

40
2
開始ページ
157
終了ページ
168
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1111/jfd.12500
出版者・発行元
WILEY

Herpesviral haematopoietic necrosis (HVHN), caused by cyprinid herpesvirus-2 (CyHV-2), has affected the commercial production of the goldfish Carassius auratus and gibelio carp Carassius auratus gibelio. High water temperature treatments are reported to reduce the mortality rate of infected goldfish and elicit immunity in the survivors. To define the mechanism by which this intervention induces resistance, clonal ginbuna Carassius auratus langsdorfii, which is closely related to both species and has been used in fish immunology, may represent a promising model species. In this study, we investigated the susceptibility of clonal ginbuna strains to CyHV-2 and the effect of high water temperature treatment on infected ginbuna and goldfish. Experimental intraperitoneal infection with CyHV-2 at 25 degrees C caused 100% mortality in ginbuna strains, which was accompanied by histopathological changes typical of HVHN. Both infected ginbuna S3n strain and goldfish, exposed to high temperature for 6 days [shifting from 25 degrees C (permissive) to 34 degrees C (non-permissive)], showed reduced mortalities after the 1st inoculation, and subsequent 2nd virus challenge to 0%, indicating induction of immunity. It was concluded that ginbuna showed a similar susceptibility and disease development in CyHV-2 infection compared to goldfish, suggesting that ginbuna can be a useful fish model for the study of CyHV-2 infection and immunity.

リンク情報
DOI
https://doi.org/10.1111/jfd.12500
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000394840600001&DestApp=WOS_CPL
ID情報
  • DOI : 10.1111/jfd.12500
  • ISSN : 0140-7775
  • eISSN : 1365-2761
  • Web of Science ID : WOS:000394840600001

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