2011年10月4日
VopV, an F-actin-binding type III secretion effector, is required for vibrio parahaemolyticus-induced enterotoxicity
Cell Host and Microbe
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- 巻
- 10
- 号
- 4
- 開始ページ
- 401
- 終了ページ
- 409
- 記述言語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1016/j.chom.2011.08.014
Vibrio parahaemolyticus, a Gram-negative halophilic bacterium that causes acute gastroenteritis in humans, is characterized by two type III secretion systems (T3SS), namely T3SS1 and T3SS2. T3SS2 is indispensable for enterotoxicity but the effector(s) involved are unknown. Here, we identify VopV as a critical effector that is required to mediate V. parahaemolyticus T3SS2-dependent enterotoxicity. VopV was found to possess multiple F-actin-binding domains and the enterotoxicity caused by VopV correlated with its F-actin-binding activity. Furthermore, a T3SS2-related secretion system and a vopV homologous gene were also involved in the enterotoxicity of a non-O1/non-O139 V. cholerae strain. These results indicate that the F-actin-targeting effector VopV is involved in enterotoxic activity of T3SS2-possessing bacterial pathogens. © 2011 Elsevier Inc.
- リンク情報
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- DOI
- https://doi.org/10.1016/j.chom.2011.08.014
- PubMed
- https://www.ncbi.nlm.nih.gov/pubmed/22018240
- Scopus
- https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=80054915314&origin=inward 本文へのリンクあり
- Scopus Citedby
- https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=80054915314&origin=inward
- ID情報
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- DOI : 10.1016/j.chom.2011.08.014
- ISSN : 1931-3128
- eISSN : 1934-6069
- PubMed ID : 22018240
- SCOPUS ID : 80054915314