2015年12月
Differential roles of dopamine D1 and D2 receptor-containing neurons of the nucleus accumbens shell in behavioral sensitization
JOURNAL OF NEUROCHEMISTRY
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- 巻
- 135
- 号
- 6
- 開始ページ
- 1232
- 終了ページ
- 1241
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1111/jnc.13380
- 出版者・発行元
- WILEY-BLACKWELL
The nucleus accumbens (Nac) mediates the reinforcing and motor stimulating properties of psychostimulants. It receives dopaminergic afferents from the ventral midbrain and is divided into two distinct subregions: shell and core. Each of these contains two subtypes of medium spiny neurons, which express either dopamine D1 (D1R) or D2 (D2R) receptors. However, functional dissociation between the two subtypes in psychostimulant response remains to be elucidated. We performed selective ablation of each subtype in the Nac shell in mice, using immunotoxin-mediated cell targeting, and examined the behavioral sensitization evoked by repeated administration of methamphetamine. The D1R cell-ablated mice exhibited delayed induction of sensitized locomotion compared to control mice, whereas the D2R cell-ablated mice showed a mildly enhanced rate of induction of sensitization. In vivo microdialysis revealed a marked blockade of the increase in extracellular dopamine in the Nac of the D1R cell-ablated animals in response to methamphetamine, indicating that the observed delay in behavioral sensitization in these mice involves an impairment in accumbal dopamine release. Our results reveal differential roles of D1R- and D2R-containing accumbal shell neurons in the development of behavioral sensitization to psychostimulants.
- リンク情報
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- DOI
- https://doi.org/10.1111/jnc.13380
- PubMed
- https://www.ncbi.nlm.nih.gov/pubmed/26442961
- Web of Science
- https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000367192100016&DestApp=WOS_CPL
- 共同研究・競争的資金等の研究課題
- 報酬行動に関わる神経回路メカニズムの解析
- ID情報
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- DOI : 10.1111/jnc.13380
- ISSN : 0022-3042
- eISSN : 1471-4159
- PubMed ID : 26442961
- Web of Science ID : WOS:000367192100016