Masahiro Sekiguchi

Profile Information

Affiliation: 小児科, 東京大学

Researcher number: 70747493
ORCID ID: https://orcid.org/0000-0002-7941-9319
J-GLOBAL ID: 202001011795198367
researchmap Member ID: R000000774

Research Areas

Education

Apr, 2016 - Mar, 2020

Reproductive, Developmental and Aging Sciences, Graduate School of Medicine, The University of Tokyo
Apr, 2005 - Mar, 2009

School of Medicine, Faculty of Medicine, The University of Tokyo
Apr, 2003 - Mar, 2005

Natural sciences III, College of Arts and Sciences, The University of Tokyo

Papers

Inhibition of the galactosyltransferase C1GALT1 reduces osteosarcoma cell proliferation by interfering with ERK signaling and cell cycle progression

Kentaro Watanabe, Keiji Tasaka, Hideto Ogata, Shota Kato, Hiroo Ueno, Katsutsugu Umeda, Tomoya Isobe, Yasuo Kubota, Masahiro Sekiguchi, Shunsuke Kimura …

Cancer Gene Therapy, Apr 15, 2024
Minimal residual disease detection by mutation-specific droplet digital PCR for leukemia/lymphoma.

Ryota Shirai, Tomoo Osumi, Dai Keino, Kazuhiko Nakabayashi, Toru Uchiyama, Masahiro Sekiguchi, Mitsuteru Hiwatari, Masanori Yoshida, Kaoru Yoshida, Yuji Yamada …

International journal of hematology, 117(6) 910-918, Jun, 2023
Turner症候群に巨大腹腔内腫瘍が合併した一例

小田啓奈, 井上秀太郎, 日高もえ, 関口昌央, 渡邊健太郎, 六反啓文, 牛久哲男, 吉田真理子, 渡谷岳行, 加藤元博

日本小児科学会雑誌, 127(2) 347-347, Feb, 2023
Transplantation using targeted busulfan for <scp>Diamond–Blackfan</scp> anemia

Shota Kato, Yoshiko Nakano, Moe Hidaka, Masahiro Sekiguchi, Kentaro Watanabe, Junya Fujimura, Motohiro Kato

Pediatrics International, 65(1), Jan, 2023
Urinary extracellular vesicles signature for diagnosis of kidney disease

Keiichi Takizawa, Koji Ueda, Masahiro Sekiguchi, Eiji Nakano, Tatsuya Nishimura, Yuko Kajiho, Shoichiro Kanda, Kenichiro Miura, Motoshi Hattori, Junya Hashimoto …

iScience, 25(11) 105416-105416, Nov, 2022
Identification of the ultrahigh-risk subgroup in neuroblastoma cases through DNA methylation analysis and its treatment exploiting cancer metabolism.

Kentaro Watanabe, Shunsuke Kimura, Masafumi Seki, Tomoya Isobe, Yasuo Kubota, Masahiro Sekiguchi, Aiko Sato-Otsubo, Mitsuteru Hiwatari, Motohiro Kato, Akira Oka …

Oncogene, 41(46) 4994-5007, Nov, 2022
神経芽腫における新規TENM 3-ALK融合遺伝子の解析(Novel ALK fusion in neuroblastoma involving TENM3, a conserved family of transmembrane protein)

樋渡光輝, 関正史, 松野良介, 吉田健一, 長澤武, 佐藤亜以子, 山本将平, 加藤元博, 渡邉健太郎, 関口昌央 …

日本癌学会総会記事, 81回 J-3016, Sep, 2022
Multi-omics analysis defines highly refractory RAS burdened immature subgroup of infant acute lymphoblastic leukemia.

Tomoya Isobe, Masatoshi Takagi, Aiko Sato-Otsubo, Akira Nishimura, Genta Nagae, Chika Yamagishi, Moe Tamura, Yosuke Tanaka, Shuhei Asada, Reina Takeda …

Nature communications, 13(1) 4501-4501, Aug 30, 2022
Low NUDT15 expression levels due to biallelic NUDT15 variants and 6-mercaptopurine intolerance.

Masanori Yoshida, Scott A Brown, Takaya Moriyama, Rina Nishii, Shin-Ichi Tsujimoto, Yuji Yamada, Kaoru Yoshida, Ryota Shirai, Tomoo Osumi, Tomoyuki Utano …

British journal of haematology, 199(2) 270-276, Jul 29, 2022
Novel TENM3-ALK fusion is an alternate mechanism for ALK activation in neuroblastoma.

Mitsuteru Hiwatari, Masafumi Seki, Ryosuke Matsuno, Kenichi Yoshida, Takeshi Nagasawa, Aiko Sato-Otsubo, Shohei Yamamoto, Motohiro Kato, Kentaro Watanabe, Masahiro Sekiguchi …

Oncogene, 41(20) 2789-2797, May, 2022
免疫抑制療法中にCOVID-19を発症した再生不良性貧血の1例

宍戸将人, 加登翔太, 中野嘉子, 中野裕樹, 岡本耕, 日高もえ, 関口昌央, 渡邉健太郎, 樋渡光輝, 加藤元博

日本小児科学会雑誌, 126(3) 561-561, Mar, 2022
Description of longitudinal tumor evolution in a case of multiply relapsed clear cell sarcoma of the kidney.

Tomoki Yaguchi, Shunsuke Kimura, Masahiro Sekiguchi, Yasuo Kubota, Masafumi Seki, Kenichi Yoshida, Yuichi Shiraishi, Keisuke Kataoka, Yoichi Fujii, Kentaro Watanabe …

Cancer reports (Hoboken, N.J.), 5(2) e1458, Feb, 2022
COVID‐19 in an adolescent with aplastic anemia undergoing immunosuppressive therapy: A case report and details of antibody testing for SARS‐CoV‐2

Shota Kato, Yoshiko Nakano, Yuki Nakano, Koh Okamoto, Nao Takasugi, Moe Hidaka, Masahiro Sekiguchi, Mitsuteru Hiwatari, Makoto Kurano, Motohiro Kato

Pediatric Blood & Cancer, Sep 5, 2021
Association of high-risk neuroblastoma classification based on expression profiles with differentiation and metabolism.

Shunsuke Kimura, Masahiro Sekiguchi, Kentaro Watanabe, Mitsuteru Hiwatarai, Masafumi Seki, Kenichi Yoshida, Tomoya Isobe, Yusuke Shiozawa, Hiromichi Suzuki, Noriko Hoshino …

PloS one, 16(1) e0245526, 2021
Integrated multiomics analysis of hepatoblastoma unravels its heterogeneity and provides novel druggable targets

Masahiro Sekiguchi, Masafumi Seki, Tomoko Kawai, Kenichi Yoshida, Misa Yoshida, Tomoya Isobe, Noriko Hoshino, Ryota Shirai, Mio Tanaka, Ryota Souzaki …

npj Precision Oncology, 4(1), Dec, 2020 Peer-reviewedLead author
KMT2A-rearranged diffuse large B-cell lymphoma in a child: a case report and molecular characterization

Shota Kato, Yasuo Kubota, Masahiro Sekiguchi, Kentaro Watanabe, Aya Shinozaki-Ushiku, Junko Takita, Mitsuteru Hiwatari

Pediatric Hematology and Oncology, 1-9, Nov 5, 2020
マルチオミックス解析による肝芽腫の治療標的NQO1、ODC1の同定

関口昌央, 関正史, 吉田健一, 田中水緒, 白井了太, 宗崎良太, 白石友一, 樋渡光輝, 加藤元博, 田口智章 …

日本癌学会総会記事, 79回 OJ7-1, Oct, 2020
マルチオミックス解析による肝芽腫の治療標的NQO1、ODC1の同定

関口昌央, 関正史, 吉田健一, 田中水緒, 白井了太, 宗崎良太, 白石友一, 樋渡光輝, 加藤元博, 田口智章 …

日本癌学会総会記事, 79回 OJ7-1, Oct, 2020
Comprehensive genetic analysis of pediatric germ cell tumors identifies potential drug targets.

Yasuo Kubota, Masafumi Seki, Tomoko Kawai, Tomoya Isobe, Misa Yoshida, Masahiro Sekiguchi, Shunsuke Kimura, Kentaro Watanabe, Aiko Sato-Otsubo, Kenichi Yoshida …

Communications biology, 3(1) 544-544, Sep 30, 2020
High prevalence of SMARCB1 constitutional abnormalities including mosaicism in malignant rhabdoid tumors.

Ryota Shirai, Tomoo Osumi, Keita Terashima, Chikako Kiyotani, Meri Uchiyama, Shinichi Tsujimoto, Masanori Yoshida, Kaoru Yoshida, Toru Uchiyama, Daisuke Tomizawa …

European journal of human genetics : EJHG, 28(8) 1124-1128, Aug, 2020 Peer-reviewed

Misc.

PREVALENCE OF GERMLINE VARIANTS IN SMARCB1 INCLUDING SOMATIC MOSAICISM IN AT/RT AND OTHER RHABDOID TUMORS

Ryota Shirai, Tomoo Osumi, Keita Terashima, Chikako Kiyotani, Meri Uchiyama, Shinichi Tsujimoto, Masanori Yoshida, Kaoru Yoshida, Toru Uchiyama, Daisuke Tomizawa …

NEURO-ONCOLOGY, 22 277-278, Dec, 2020
ターゲットキャプチャー法による小児胚細胞腫瘍の変異解析

久保田泰央, 関正史, 関口昌央, 吉田美沙, 吉田健一, 樋渡光輝, 宮野悟, 岡明, 林泰秀, 田中祐吉 …

日本小児科学会雑誌, 123(2) 263-263, Feb, 2019
Comprehensive genomic analysis of hepatoblastoma reveals its genetic heterogeneity and provides novel therapeutic targets

Masahiro Sekiguchi, Junko Takita

The Japanese Journal of Pediatric Hematology/Oncology, 56(5) 361-369, 2019 Lead author
Sibling Cases of Pleuropulmonary Blastoma with Compound Heterozygous DICER1 Mutations

Yuji Yamada, Shota Kato, Ryota Shirai, Tomoo Osumi, Chikako Kiyotani, Toshihiko Watanabe, Tomoro Hishiki, Masahiro Sekiguchi, Masafumi Seki, Junko Takita …

PEDIATRIC BLOOD & CANCER, 65 S74-S75, Nov, 2018
造血器および固形腫瘍におけるSTAT3阻害剤、cucurbitacin Iの抗腫瘍効果の検討(Cucurbitacin I, JAK-STAT signaling pathway inhibitor with antitumor activity against cancer cells)

樋渡光輝, 渡邉健太郎, 木村俊介, 関口昌央, 久保田泰央, 岡明, 滝田順子

臨床血液, 59(9) 1700-1700, Sep, 2018
統合的オミクス解析による膵芽腫の分子病態の解明

磯部知弥, 関正史, 吉田健一, 関口昌央, 塩澤裕介, 木村俊介, 吉田美沙, 河合智子, 秋山政晴, 藤村純也 …

日本小児科学会雑誌, 122(2) 235-235, Feb, 2018
Genetic and Epigenetic Analyses of Hepatoblastoma Identify Subgroups with Different Clinical and Biological Features

M. Sekiguchi, M. Seki, T. Kawai, T. Isobe, K. Yoshida, M. Yoshida, N. Hoshino, Y. Shiraishi, R. Souzaki, K. Watanabe …

PEDIATRIC BLOOD & CANCER, 64 S72-S73, Nov, 2017
STAT3 Inhibitor, Cucurbitacin I, Synergies with Crizotinib in Vitro Preclinical Models of Neuroblastoma

Mitsuteru Hiwatari, Masafumi Seki, Masahiro Sekiguchi, Shun-suke Kimura, Yasuo Kubota, Kentaro Watanabe, Akira Oka, Junko Takita

PEDIATRIC BLOOD & CANCER, 64 S103-S104, Nov, 2017
The Genetic Basis of Progression and Relapse in CCSK

Tomoki Yaguchi, Shunsuke Kimura, Masahumi Seki, Masahiro Sekiguchi, Kenichi Yoshida, Yuichi Shiraishi, Kenichi Chiba, Yusuke Shiozawa, Keisuke Kataoka, Yoichi Fuji …

PEDIATRIC BLOOD & CANCER, 64 S50-S50, Nov, 2017
A 10-year-old Girl with Immune Thrombocytopenia Developing after Allogeneic Bone Marrow Transplantation for Relapsed Philadelphia-positive Acute Lymphoblastic Leukemia

Ayako Mano, Shigo Ikeyama, Koichi Takamizawa, Yuichi Mitani, Masahiro Sekiguchi, Masafumi Seki, Mitsuteru Hiwatari, Junko Takita

PEDIATRIC BLOOD & CANCER, 64 S76-S77, Nov, 2017
Integrated Genetic and Epigenetic Analysis of Hepatoblastoma

Masahiro Sekiguchi, Junko Takita

PEDIATRIC BLOOD & CANCER, 64 S5-S6, Nov, 2017
網羅的遺伝子解析を行った両側ウィルムス腫瘍の一例(Comprehensive genetic analysis of a case with bilateral Wilms tumor and nephrogenic rest)

真野絢子, 樋渡光輝, 関正史, 関口昌央, 西村良成, 藤木俊寛, 前馬秀昭, 酒井清祥, 吉田健一, 片岡圭亮 …

日本小児血液・がん学会雑誌, 53(4) 305-305, Nov, 2016
生存中の再発神経芽腫の3例

加登翔太, 関口昌央, 半谷まゆみ, 久保田泰央, 樋渡光輝, 滝田順子, 岡明

日本小児科学会雑誌, 120(2) 379-379, Feb, 2016
再発を繰り返し、剖検に至った難治性腎明細胞肉腫の一例

小川陽介, 久保田泰央, 関口昌央, 樋渡光輝, 滝田順子, 山澤翔, 阿部浩幸, 柴原純二, 岡明

日本小児科学会雑誌, 120(2) 380-380, Feb, 2016
中枢神経浸潤を伴うALCLに対し大量MTX療法と髄注を強化した化学療法を行った2歳男児例

関口昌央, 樋渡光輝, 半谷まゆみ, 久保田泰央, 滝田順子, 岡明

日本小児科学会雑誌, 120(2) 419-419, Feb, 2016
22q11.2欠失症候群に合併した慢性活動性EBウイルス感染症(CAEBV)の1例

半谷まゆみ, 清水信隆, 加藤元博, 進藤考洋, 犬塚亮, 平田陽一郎, 関口昌央, 久保田泰央, 樋渡光輝, 滝田順子 …

日本小児科学会雑誌, 120(1) 95-95, Jan, 2016
ユーイング肉腫再発時に甲状腺がん微小肺転移が発見された一例(A case of micro lung metastasis of thyroid cancer complicated with recurrent Ewing sarcoma)

関口昌央, 関正史, 加藤元博, 渡邉健太郎, 樋渡光輝, 丹羽隆善, 河野博隆, 岡明, 滝田順子

日本小児血液・がん学会雑誌, 52(4) 294-294, Oct, 2015
過去10年間に当院で治療した小児骨肉腫の検討(Analysis of pediatric osteosarcoma cases treated in our hospital: Case series)

半谷まゆみ, 関口昌央, 久保田泰央, 関正史, 樋渡光輝, 岡明, 滝田順子

日本小児血液・がん学会雑誌, 52(4) 296-296, Oct, 2015
22q11.2欠失症候群に慢性活動性EBウイルス感染症を合併した一症例(Chronic active EB virus infection in a patient with deletion of 22q11.2)

米田立, 清水信隆, 加藤元博, 半谷まゆみ, 今留謙一, 進藤考洋, 関口昌央, 平田陽一郎, 久保田泰央, 犬塚亮 …

日本小児血液・がん学会雑誌, 52(4) 366-366, Oct, 2015
先天性角化不全症の1例

須川正啓, 加藤元博, 渡邉健太郎, 関口昌央, 樋渡光輝, 滝田順子, 岡明

日本小児科学会雑誌, 119(8) 1278-1278, Aug, 2015

Presentations

Fundamentals for Genetic Research Projects in Pediatric Oncology

Sep 26, 2019 Invited
Comprehensive genetic and epigenetic analyses identify high expression of ODC1 as a therapeutic target in high-risk hepatoblastoma

Masahiro Sekiguchi, Masafumi Seki, Tomoko Kawai, Tomoya Isobe, Kenichi Yoshida, Misa Yoshida, Ryota Shirai, Ryota Souzaki, Kenichi Kohashi, Yuichi Shiraishi, Noriko Hoshino, Yusuke Sato, Yoichi Fujii, Kentaro Watanabe, Yuki Arakawa, Katsuyoshi Koh, Yasuhide Hayashi, Tomoaki Taguchi, Motohiro Kato, Masashi Sanada, Yukichi Tanaka, Satoru Miyano, Kenichiro Hata, Seishi Ogawa, Junko Takita

Nov 14, 2018
Comprehensive epigenetic analysis identifies NQO1 as a potential therapeutic target of high-risk hepatoblastoma

Sep 27, 2018
Genetic and Epigenetic Analyses of Hepatoblastoma Identify Subgroups with Different Clinical and Biological Features

Masahiro Sekiguchi, Masafumi Seki, Tomoko Kawai, Tomoya Isobe, Kenichi Yoshida, Misa Yoshida, Noriko Hoshino, Yuichi Shiraishi, Ryota Souzaki, Kentaro Watanabe, Yuki Arakawa, Katsuyoshi Koh, Yasuhide Hayashi, Tomoaki Taguchi, Masashi Sanada, Yukichi Tanaka, Satoru Miyano, Kenichiro Hata, Seishi Ogawa, Junko Takita

The 49th Congress of the International Society of Paediatric Oncology (SIOP 2017), Oct 15, 2017

Professional Memberships

Jul, 2018 - Present

日本人類遺伝学会
Sep, 2016 - Present

日本癌学会
Oct, 2014 - Present

日本血液学会
Sep, 2014 - Present

日本造血細胞移植学会
Oct, 2013 - Present

日本小児血液・がん学会
Jan, 2011 - Present

日本小児科学会

Research Projects

間葉系幹細胞の胚葉起源に基づくユーイング肉腫の新規分類法の確立とその応用

科学研究費助成事業, 若手研究, 日本学術振興会, Apr, 2021 - Mar, 2023

関口昌央
Multiomics analysis of hepatoblastoma

Children’s Cancer Association of Japan, Oct, 2018 - Sep, 2020

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