論文

査読有り 筆頭著者 責任著者
2013年11月

Effects of stimulus spatial frequency, size, and luminance contrast on orientation tuning of neurons in the dorsal lateral geniculate nucleus of cat

NEUROSCIENCE RESEARCH
  • Tomoyuki Naito
  • ,
  • Masahiro Okamoto
  • ,
  • Osamu Sadakane
  • ,
  • Satoshi Shimegi
  • ,
  • Hironobu Osaki
  • ,
  • Shin-Ichiro Hara
  • ,
  • Akihiro Kimura
  • ,
  • Ayako Ishikawa
  • ,
  • Naofumi Suematsu
  • ,
  • Hiromichi Sato

77
3
開始ページ
143
終了ページ
154
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1016/j.neures.2013.08.009
出版者・発行元
ELSEVIER IRELAND LTD

It is generally thought that orientation selectivity first appears in the primary visual cortex (V1), whereas neurons in the lateral geniculate nucleus (LGN), an input source for V1, are thought to be insensitive to stimulus orientation. Here we show that increasing both the spatial frequency and size of the grating stimuli beyond their respective optimal values strongly enhance the orientation tuning of LGN neurons. The resulting orientation tuning was clearly contrast-invariant. Furthermore, blocking intrathalamic inhibition by iontophoretically administering gamma-aminobutyric acid (GABA)(A) receptor antagonists, such as bicuculline and GABAzine, slightly but significantly weakened the contrast invariance. Our results suggest that orientation tuning in the LGN is caused by an elliptical classical receptive field and orientation-tuned surround suppression, and that its contrast invariance is ensured by local GABA(A) inhibition. This contrast-invariant orientation tuning in LGN neurons may contribute to the contrast-invariant orientation tuning seen in V1 neurons. (C) 2013 The Authors. Published by Elsevier Ireland Ltd and the Japan Neuroscience Society. All rights reserved.

リンク情報
DOI
https://doi.org/10.1016/j.neures.2013.08.009
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/24055599
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000327283200004&DestApp=WOS_CPL
ID情報
  • DOI : 10.1016/j.neures.2013.08.009
  • ISSN : 0168-0102
  • eISSN : 1872-8111
  • PubMed ID : 24055599
  • Web of Science ID : WOS:000327283200004

エクスポート
BibTeX RIS