論文

査読有り 筆頭著者 国際誌
2017年6月

Identification of the gene-regulatory landscape in skeletal development and potential links to skeletal regeneration.

Regenerative therapy
  • Hironori Hojo
  • ,
  • Ung-Il Chung
  • ,
  • Shinsuke Ohba

6
開始ページ
100
終了ページ
107
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1016/j.reth.2017.04.001
出版者・発行元
ELSEVIER SCIENCE BV

A class of gene-regulatory elements called enhancers are the main mediators controlling quantitative, temporal and spatial gene expressions. In the course of evolution, the enhancer landscape of higher organisms such as mammals has become quite complex, exerting biological functions precisely and coordinately. In mammalian skeletal development, the master transcription factors Sox9, Runx2 and Sp7/Osterix function primarily through enhancers on the genome to achieve specification and differentiation of skeletal cells. Recently developed genome-scale analyses have shed light on multiple layers of gene regulations, uncovering not only the primary mode of actions of these transcription factors on skeletal enhancers, but also the relation of the epigenetic landscape to three-dimensional chromatin architecture. Here, we review findings on the emerging framework of gene-regulatory networks involved in skeletal development. We further discuss the power of genome-scale analyses to provide new insights into genetic diseases and regenerative medicine in skeletal tissues.

リンク情報
DOI
https://doi.org/10.1016/j.reth.2017.04.001
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/30271844
PubMed Central
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6134913
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000418835000012&DestApp=WOS_CPL
URL
http://www.scopus.com/inward/record.url?eid=2-s2.0-85041018481&partnerID=MN8TOARS
ID情報
  • DOI : 10.1016/j.reth.2017.04.001
  • ISSN : 2352-3204
  • ORCIDのPut Code : 84496218
  • PubMed ID : 30271844
  • PubMed Central 記事ID : PMC6134913
  • SCOPUS ID : 85041018481
  • Web of Science ID : WOS:000418835000012

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