2017年6月
Identification of the gene-regulatory landscape in skeletal development and potential links to skeletal regeneration.
Regenerative therapy
- ,
- ,
- 巻
- 6
- 号
- 開始ページ
- 100
- 終了ページ
- 107
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1016/j.reth.2017.04.001
- 出版者・発行元
- ELSEVIER SCIENCE BV
A class of gene-regulatory elements called enhancers are the main mediators controlling quantitative, temporal and spatial gene expressions. In the course of evolution, the enhancer landscape of higher organisms such as mammals has become quite complex, exerting biological functions precisely and coordinately. In mammalian skeletal development, the master transcription factors Sox9, Runx2 and Sp7/Osterix function primarily through enhancers on the genome to achieve specification and differentiation of skeletal cells. Recently developed genome-scale analyses have shed light on multiple layers of gene regulations, uncovering not only the primary mode of actions of these transcription factors on skeletal enhancers, but also the relation of the epigenetic landscape to three-dimensional chromatin architecture. Here, we review findings on the emerging framework of gene-regulatory networks involved in skeletal development. We further discuss the power of genome-scale analyses to provide new insights into genetic diseases and regenerative medicine in skeletal tissues.
- リンク情報
-
- DOI
- https://doi.org/10.1016/j.reth.2017.04.001
- PubMed
- https://www.ncbi.nlm.nih.gov/pubmed/30271844
- PubMed Central
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6134913
- Web of Science
- https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000418835000012&DestApp=WOS_CPL
- URL
- http://www.scopus.com/inward/record.url?eid=2-s2.0-85041018481&partnerID=MN8TOARS
- ID情報
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- DOI : 10.1016/j.reth.2017.04.001
- ISSN : 2352-3204
- ORCIDのPut Code : 84496218
- PubMed ID : 30271844
- PubMed Central 記事ID : PMC6134913
- SCOPUS ID : 85041018481
- Web of Science ID : WOS:000418835000012