Hiroko Okawa

Profile Information

Degree: P.h.D.(Mar, 2016, Osaka University)

Researcher number: 00781296
J-GLOBAL ID: 201901019710207338
researchmap Member ID: B000374577

Research Interests

Research Areas

Research History

Apr, 2020 - Present

助教, 分子・再生歯科補綴学分野, 東北大学大学院歯学研究科
Mar, 2018 - Mar, 2020

University of California, Los Angeles
Mar, 2018 - Mar, 2020

Graduate School of Dentistry, Tohoku University
Apr, 2016 - Feb, 2018

医員, 東北大学病院
Apr, 2011 - Mar, 2012

Dental Hospital, Osaka University

Education

Apr, 2012 - Mar, 2016

Graduate School of Dentistry, Osaka University
Apr, 2005 - Mar, 2011

Dental School, Okayama University

Awards

Mar, 2018

若手リーダー研究者海外派遣プログラム, 東北大学

大川博子
2016

歯科医学を中心とした総合的な研究を推進する集い優秀発表賞, 日本歯科医学会

大川博子
2015

優秀海外発表大学院生奨励賞, 大阪大学歯学会

大川博子
2015

デンツプライ賞, 日本口腔インプラント学会

大川博子
Jun, 2014

Arthur R. Frechette 若手補綴学研究者賞第1位, 国際歯科研究学会（IADR）

大川博子

Papers

Intermittent compressive force induces cell cycling and reduces apoptosis in embryoid bodies of mouse induced pluripotent stem cells

Jeeranan Manokawinchoke, Phoonsuk Limraksasin, Hiroko Okawa, Prasit Pavasant, Hiroshi Egusa, Thanaphum Osathanon

International Journal of Oral Science, 14(1), Dec, 2022 Peer-reviewed
Oral microbial extracellular DNA initiates periodontitis through gingival degradation by fibroblast-derived cathepsin K in mice

Takeru Kondo, Hiroko Okawa, Akishige Hokugo, Bhumika Shokeen, Oskar Sundberg, Yiying Zheng, Charles E. McKenna, Renate Lux, Ichiro Nishimura

Communications Biology, 5(1) 962-962, Sep 14, 2022 Peer-reviewed
Fluorescent risedronate analogue 800CW-pRIS improves tooth extraction-associated abnormal wound healing in zoledronate-treated mice

Hiroko Okawa, Takeru Kondo, Akishige Hokugo, Philip Cherian, Oskar Sundberg, Jesus J. Campagna, Boris A. Kashemirov, Varghese John, Shuting Sun, Frank H. Ebetino …

Communications Medicine, 2(1) 112-112, Sep 5, 2022 Peer-reviewed
Mechanism of bisphosphonate-related osteonecrosis of the jaw (BRONJ) revealed by targeted removal of legacy bisphosphonate from jawbone using equilibrium competing inert hydroxymethylene diphosphonate

Hiroko Okawa, Takeru Kondo, Akishige Hokugo, Philip Cherian, Jesus J Campagna, Nicholas A Lentini, Eric C Sung, Samantha Chiang, Yi-Ling Lin, Frank H Ebetino …

eLife, 11, Aug 26, 2022 Peer-reviewed
Application of Shear Stress for Enhanced Osteogenic Differentiation of Mouse Induced Pluripotent Stem Cells

Phoonsuk Limraksasin, Praphawi Nattasit, Jeeranan Manokawinchoke, Watcharaphol Tiskratok, Naruephorn Vinaikosol, Hiroko Okawa, Chalida Nakalekha Limjeerajarus, Nuttapol Limjeerajarus, Prasit Pavasant, Thanaphum Osathanon …

Jul 25, 2022 Peer-reviewed
Rapid and Efficient Generation of Cartilage Pellets from Mouse Induced Pluripotent Stem Cells by Transcriptional Activation of BMP-4 with Shaking Culture.

Zhang M, Niibe K, Kondo T, Limraksasin P, Okawa H, Miao X, Kamano Y, Yamada M, Jiang X, Egusa H

J Tissue Eng., 13(20417314221114616), Jul, 2022 Peer-reviewed
Cell-Based Double-Screening Method to Identify a Reliable Candidate for Osteogenesis-Targeting Compounds

Sho Fukuyasu, Hiroki Kayashima, Akihito Moribayashi, Shu Matsuoka, Atsuhiro Nagasaki, Hiroko Okawa, Hirofumi Yatani, Makio Saeki, Hiroshi Egusa

Biomedicines, 10(2) 426-426, Feb 11, 2022 Peer-reviewed
Therapeutic downregulation of neuronal PAS domain 2 (Npas2) promotes surgical skin wound healing

Yoichiro Shibuya, Akishige Hokugo, Hiroko Okawa, Takeru Kondo, Daniel Khalil, Lixin Wang, Yvonne Roca, Adam Clements, Hodaka Sasaki, Ella Berry …

eLife, 11, Jan 18, 2022 Peer-reviewed
Cyclic pressure-induced cytokines from gingival fibroblasts stimulate osteoclast activity: Clinical implications for alveolar bone loss in denture wearers.

Akashi Y, Nagasaki A, Okawa H, Matsumoto T, Kondo T, Yatani H, Nishimura I, Egusa H

Journal of prosthodontic research, 2022 Peer-reviewed
Point-of-care antimicrobial coating protects orthopaedic implants from bacterial challenge

Weixian Xi, Vishal Hegde, Stephen D. Zoller, Howard Y. Park, Christopher M. Hart, Takeru Kondo, Christopher D. Hamad, Yan Hu, Amanda H. Loftin, Daniel O. Johansen …

Nature Communications, 12(1) 5473-5473, Dec, 2021 Peer-reviewed
Shaking culture enhances chondrogenic differentiation of mouse induced pluripotent stem cell constructs

Phoonsuk Limraksasin, Yukihiro Kosaka, Maolin Zhang, Naohiro Horie, Takeru Kondo, Hiroko Okawa, Masahiro Yamada, Hiroshi Egusa

Scientific Reports, 10(1), Dec, 2020 Peer-reviewed
Size-Optimized Microspace Culture Facilitates Differentiation of Mouse Induced Pluripotent Stem Cells into Osteoid-Rich Bone Constructs

Phoonsuk Limraksasin, Hiroko Okawa, Maolin Zhang, Takeru Kondo, Thanaphum Osathanon, Prasit Pavasant, Hiroshi Egusa

Stem Cells International, 2020 1-14, May 14, 2020 Peer-reviewed
In vitro fabrication of hybrid bone/cartilage complex using mouse induced pluripotent stem cells

Limraksasin P, Kondo T, Zhang M, Okawa H, Osathanon T, Pavasant P, Egusa H

Int J Mol Sci, 21(2) in press-581, Jan, 2020 Peer-reviewed
Implications of the circadian clock in implant dentistry

Okawa H, Egusa H, Nishimura I

Dental Materials Journal, Nov, 2019 Peer-reviewed
Rescue bisphosphonate treatment of alveolar bone improves extraction socket healing and reduces osteonecrosis in zoledronate-treated mice.

Hokugo A, Kanayama K, Sun S, Morinaga K, Sun Y, Wu Q, Sasaki H, Okawa H, Evans C, Ebetino FH …

Bone, 123 115-128, Jun, 2019 Peer-reviewed
Neuronal PAS Domain 2 (Npas2)-Deficient Fibroblasts Accelerate Skin Wound Healing and Dermal Collagen Reconstruction.

Sasaki H, Hokugo A, Wang L, Morinaga K, Ngo JT, Okawa H, Nishimura I

Anatomical record (Hoboken, N.J. : 2007), Mar, 2019 Peer-reviewed
Neuronal PAS domain 2 (Npas2) facilitated osseointegration of titanium implant with rough surface through a neuroskeletal mechanism.

Kenzo Morinaga, Hodaka Sasaki, Sil Park, Akishige Hokugo, Hiroko Okawa, Yu Tahara, Christopher S Colwell, Ichiro Nishimura

Biomaterials, 192 62-74, Feb, 2019 Peer-reviewed
Binding of PICK1 PDZ domain with calcineurin B regulates osteoclast differentiation

Yuya Kamano, Jun Watanabe, Tsutomu Iida, Takeru Kondo, Hiroko Okawa, Hirofumi Yatani, Makio Saeki, Hiroshi Egusa

Biochemical and Biophysical Research Communications, 496(1) 83-88, Jan 29, 2018 Peer-reviewed
Gingival Fibroblasts as Autologous Feeders for Induced Pluripotent Stem Cells

G. Yu, H. Okawa, K. Okita, Y. Kamano, F. Wang, M. Saeki, H. Yatani, H. Egusa

JOURNAL OF DENTAL RESEARCH, 95(1) 110-118, Jan, 2016 Peer-reviewed
Scaffold-Free Fabrication of Osteoinductive Cellular Constructs Using Mouse Gingiva-Derived Induced Pluripotent Stem Cells

Hiroko Okawa, Hiroki Kayashima, Jun-Ichi Sasaki, Jiro Miura, Yuya Kamano, Yukihiro Kosaka, Satoshi Imazato, Hirofumi Yatani, Takuya Matsumoto, Hiroshi Egusa

STEM CELLS INTERNATIONAL, 2016 6240794, 2016 Peer-reviewed

Misc.

ヒトiPS細胞に低酸素培養を応用した再生医療用骨組織の作製

大川博子, 江草宏

日本歯科医学会誌, 36 60-60, Mar, 2017
iPS細胞を用いた唾液腺再生への試み

小野瞳, 尾花綾, 宇佐美悠, 江草宏, 大川博子, 山城隆, 野原幹司, 阪井丘芳

日本口腔科学会雑誌, 63(4) 393-393, Sep, 2014
歯肉を用いた医療応用に安全なiPS細胞の開発新たな再生歯科医療技術の創成に向けて

江草宏, 于冠男, 鎌野優弥, 大川博子, 山本治毅, 矢谷博文

日本歯科医学会誌, 33 54-58, Mar, 2014

Presentations

OFS, Novel Sentinel Imaging Probes for Early Diagnosis of Periodontitis

Hiroko Okawa, Akishige Hokugo, Lixin Wang, Daniel Khalil, Shota Homma, Eric Richard, Yiying Zheng, Boris Kashemirov, Reza Jarrahy, Charles McKenna, Ichiro Nishimura

米国骨代謝学会（ASBMR), Sep, 2019
Enhanced osteogenesis of mouse BMSC by Npas2 down-regulation

Hiroko Okawa, Akishige Hokugo, Ichiro Nishimura

国際歯科研究学会（IADR）, Jun, 2019
iPS細胞は歯科補綴学にどのように生かされるのか？

黄地健仁, 新部邦透, 大川博子, 帆足有理恵

第126回日本補綴歯科学会, Jul, 2017
Vertical Bone Augmentation Using iPS Cell Constructs with Simvastatin

Okawa H, Kayashima H, Yamamoto H, Yatani H, Egusa H

国際歯科研究学会（IADR）, Jun, 2014

Professional Memberships

Research Projects

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Grants-in-Aid for Scientific Research Grant-in-Aid for Early-Career Scientists, Grant-in-Aid for Early-Career Scientists, Japan Society for the Promotion of Science, Apr, 2022 - Mar, 2024
Development of a method for the endochondral alveolar bone tissue engineering using iPS cells

Grants-in-Aid for Scientific Research, Grant-in-Aid for Challenging Exploratory Research, Japan Society for the Promotion of Science, Apr, 2016 - Mar, 2018

Egusa Hiroshi, SAITO Masahiro, FUKUMOTO Satoshi, OKAWA Hiroko, KOSAKA Yukihiro
ヒトiPS細胞に低酸素培養を応用した三次元骨様組織の作製およびその骨組織再生効果

研究活動スタート支援, 日本学術振興会, Sep, 2016 - Mar, 2018

大川博子

Industrial Property Rights

特願2017-67295 ヒトiPS細胞を用いた骨芽細胞塊の作製法

江草宏, 大川博子

Profile Information

Research Interests

Research Areas

Research History

Education

Awards

Papers

Misc.

Presentations

Professional Memberships

Research Projects

Industrial Property Rights

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