2020年4月2日
Reevaluation of CBE value of BPA for hepatocytes.
Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine
- ,
- ,
- 巻
- 161
- 号
- 開始ページ
- 109159
- 終了ページ
- 109159
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1016/j.apradiso.2020.109159
The compound biological effectiveness (CBE) value of boronophenylalanine (BPA) for hepatocytes was experimentally determined for the purpose of boron neutron capture therapy (BNCT) for liver tumors. In this study, the critical reevaluation of previous value was performed. In previous experimental studies, the contribution of β component of dose was ignored in the response curve to X-ray. X-ray dose cell survival curves were estimated by combining the α/β values obtained in the ordinary micronucleus (MN) assay with the curve of MN-negative cell fraction (MN(-)F) to dose. This curve was compared to the boron neutron capture reaction (BNCR) dose curve. As a result, the CBE value was 4 at doses close to 0 Gy, decreasing to about 1.0 at doses close to 4.5 Gy. The new value is smaller than the previous value 4.2. This indicates that the bioequivalent dose to normal liver is lower than previously expected. Therefore, higher doses can be given to the tumor.
- リンク情報
- ID情報
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- DOI : 10.1016/j.apradiso.2020.109159
- PubMed ID : 32250845