論文

2021年12月

Evaluation of a treatment planning system developed for clinical boron neutron capture therapy and validation against an independent Monte Carlo dose calculation system

Radiation Oncology
  • Naonori Hu
  • ,
  • Hiroki Tanaka
  • ,
  • Ryo Kakino
  • ,
  • Syuushi Yoshikawa
  • ,
  • Mamoru Miyao
  • ,
  • Kazuhiko Akita
  • ,
  • Kayako Isohashi
  • ,
  • Teruhito Aihara
  • ,
  • Keiji Nihei
  • ,
  • Koji Ono

16
1
記述言語
掲載種別
研究論文(学術雑誌)
DOI
10.1186/s13014-021-01968-2
出版者・発行元
Springer Science and Business Media LLC

<title>Abstract</title>Boron neutron capture therapy (BNCT) for the treatment of unresectable, locally advanced, and recurrent carcinoma of the head and neck cancer has been approved by the Japanese government for reimbursement under the national health insurance as of June 2020. A new treatment planning system for clinical BNCT has been developed by Sumitomo Heavy Industries, Ltd. (Sumitomo), NeuCure® Dose Engine. To safely implement this system for clinical use, the simulated neutron flux and gamma ray dose rate inside a water phantom was compared against experimental measurements. Furthermore, to validate and verify the new planning system, the dose distribution inside an anthropomorphic head phantom was compared against a BNCT treatment planning system SERA and an in-house developed Monte Carlo dose calculation program. The simulated results closely matched the experimental results, within 5% for the thermal neutron flux and 10% for the gamma ray dose rate. The dose distribution inside the head phantom closely matched with SERA and the in-house developed dose calculation program, within 3% for the tumour and a difference of 0.3 Gyw for the brain.

リンク情報
DOI
https://doi.org/10.1186/s13014-021-01968-2
URL
https://link.springer.com/content/pdf/10.1186/s13014-021-01968-2.pdf
URL
https://link.springer.com/article/10.1186/s13014-021-01968-2/fulltext.html
ID情報
  • DOI : 10.1186/s13014-021-01968-2
  • eISSN : 1748-717X

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