2011年12月
Magnifying narrowband imaging is more accurate than conventional white-light imaging in diagnosis of gastric mucosal cancer
Gastroenterology
- 巻
- 141
- 号
- 6
- 開始ページ
- 2017
- 終了ページ
- e3
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1053/j.gastro.2011.08.007
Background &
Aims: It is difficult to accurately diagnose patients with depressed gastric mucosal cancer based on conventional white-light imaging (C-WLI) endoscopy. We compared the real-time diagnostic yield of C-WLI for small, depressed gastric mucosal cancers with that of magnifying narrow-band imaging (M-NBI). Methods: We performed a multicenter, prospective, randomized, controlled trial of patients with undiagnosed depressed lesions ≤10 mm in diameter identified by esophagogastroduodenoscopy. Patients were randomly assigned to groups that were analyzed by C-WLI (n = 176) or M-NBI (n = 177) immediately after detection
the C-WLI group received M-NBI after C-WLI. We compared the diagnostic accuracy, sensitivity, and specificity between C-WLI and M-NBI and assessed the diagnostic yield of M-NBI conducted in conjunction with C-WLI. Results: Overall, 40 gastric cancers (20 in each group) were identified. The median diagnostic values for M-NBI and C-WLI were as follows: accuracy, 90.4% and 64.8%
sensitivity, 60.0% and 40.0%
and specificity, 94.3% and 67.9%, respectively. The accuracy and specificity of M-NBI were greater than those of C-WLI (P <
.001)
the difference in sensitivity was not significant (P =.34). The combination of M-NBI with C-WLI significantly enhanced performance compared with C-WLI alone
accuracy increased from (median) 64.8% to 96.6% (P <
.001), sensitivity increased from 40.0% to 95.0% (P <
.001), and specificity increased from 67.9% to 96.8% (P <
.001). Conclusions: M-NBI, in conjunction with C-WLI, identifies small, depressed gastric mucosal cancers with 96.6% accuracy, 95.0% sensitivity, and 96.8% specificity. These values are better than for C-WLI or M-NBI alone. © 2011 AGA Institute.
Aims: It is difficult to accurately diagnose patients with depressed gastric mucosal cancer based on conventional white-light imaging (C-WLI) endoscopy. We compared the real-time diagnostic yield of C-WLI for small, depressed gastric mucosal cancers with that of magnifying narrow-band imaging (M-NBI). Methods: We performed a multicenter, prospective, randomized, controlled trial of patients with undiagnosed depressed lesions ≤10 mm in diameter identified by esophagogastroduodenoscopy. Patients were randomly assigned to groups that were analyzed by C-WLI (n = 176) or M-NBI (n = 177) immediately after detection
the C-WLI group received M-NBI after C-WLI. We compared the diagnostic accuracy, sensitivity, and specificity between C-WLI and M-NBI and assessed the diagnostic yield of M-NBI conducted in conjunction with C-WLI. Results: Overall, 40 gastric cancers (20 in each group) were identified. The median diagnostic values for M-NBI and C-WLI were as follows: accuracy, 90.4% and 64.8%
sensitivity, 60.0% and 40.0%
and specificity, 94.3% and 67.9%, respectively. The accuracy and specificity of M-NBI were greater than those of C-WLI (P <
.001)
the difference in sensitivity was not significant (P =.34). The combination of M-NBI with C-WLI significantly enhanced performance compared with C-WLI alone
accuracy increased from (median) 64.8% to 96.6% (P <
.001), sensitivity increased from 40.0% to 95.0% (P <
.001), and specificity increased from 67.9% to 96.8% (P <
.001). Conclusions: M-NBI, in conjunction with C-WLI, identifies small, depressed gastric mucosal cancers with 96.6% accuracy, 95.0% sensitivity, and 96.8% specificity. These values are better than for C-WLI or M-NBI alone. © 2011 AGA Institute.
- リンク情報
- ID情報
-
- DOI : 10.1053/j.gastro.2011.08.007
- ISSN : 0016-5085
- ISSN : 1528-0012
- ORCIDのPut Code : 12220327
- PubMed ID : 21856268
- SCOPUS ID : 81855228101