Hiroshi Ohno

Profile Information

Degree: 博士（医学）(筑波大学)

J-GLOBAL ID: 201901013847129204
researchmap Member ID: B000354081

Research Interests

Research Areas

Life sciences / Metabolism and endocrinology /

Research History

Jan, 2022 - Present

University of Tsukuba
Apr, 2019 - Dec, 2021

筑波大学
Apr, 2016 - Mar, 2019

University of Tsukuba

Education

Apr, 2015 - Mar, 2019

University of Tsukuba
Apr, 2013 - Mar, 2015

University of Tsukuba
Apr, 2009 - Mar, 2013

Department of Medicinal and Life Science, Faculty of Pharmaceutical Sciences, Tokyo University of Science

Papers

Rhomboid protease RHBDL4/RHBDD1 cleaves SREBP-1c at endoplasmic reticulum monitoring and regulating fatty acids.

Song-Iee Han, Masanori Nakakuki, Yoshimi Nakagawa, Yunong Wang, Masaya Araki, Yuta Yamamoto, Hiroaki Tokiwa, Hiroyuki Takeda, Yuhei Mizunoe, Kaori Motomura …

PNAS nexus, 2(11) pgad351, Nov, 2023
Single-cell transcriptome profiling of pancreatic islets from early diabetic mice identifies Anxa10 for Ca2+ allostasis toward β-cell failure.

Kaori Motomura, Takashi Matsuzaka, Shigeyuki Shichino, Tatsuro Ogawa, Hao Pan, Takuya Nakajima, Yasuhito Asano, Toshitsugu Okayama, Tomoyo Takeuchi, Hiroshi Ohno …

Diabetes, Oct 23, 2023
Loss of CtBP2 may be a mechanistic link between metabolic derangements and progressive impairment of pancreatic β cell function.

Motohiro Sekiya, Yang Ma, Kenta Kainoh, Kenji Saito, Daichi Yamazaki, Tomomi Tsuyuzaki, Wanpei Chen, Putu Indah Paramita Adi Putri, Hiroshi Ohno, Takafumi Miyamoto …

Cell reports, 112914-112914, Aug 1, 2023
Hepatocyte- or macrophage-specific SREBP-1a deficiency in mice exacerbates methionine- and choline-deficient diet-induced nonalcoholic fatty liver disease.

Masaya Araki, Yoshimi Nakagawa, Hodaka Saito, Yasunari Yamada, Song-Iee Han, Yuhei Mizunoe, Hiroshi Ohno, Takafumi Miyamoto, Motohiro Sekiya, Takashi Matsuzaka …

American journal of physiology. Gastrointestinal and liver physiology, 323(6) G627-G639, Dec 1, 2022 Peer-reviewed
Morphological and functional adaptation of pancreatic islet blood vessels to insulin resistance is impaired in diabetic db/db mice

Yuka Okajima, Takashi Matsuzaka, Shun Miyazaki, Kaori Motomura, Hiroshi Ohno, Rahul Sharma, Takuya Shimura, Nurani Istiqamah, Song-Iee Han, Yuhei Mizunoe …

Biochimica et Biophysica Acta - Molecular Basis of Disease, 1868(4), Jan, 2022 Peer-reviewed
Rhomboid protease RHBDL4/RHBDD1 cleaves SREBP-1c at ER monitoring and regulating fatty acids

Han SI, Nakakuki M, Nakagawa Y, Wang Y, Araki M, Yamamoto Y, Tokiwa H, Takeda H, Mizunoe Y, Motomura K …

Aug, 2021
Rapid manipulation of mitochondrial morphology in a living cell with iCMM

Takafumi Miyamoto, Hideki Uosaki, Yuhei Mizunoe, Song-Iee Han, Satoi Goto, Daisuke Yamanaka, Masato Masuda, Yosuke Yoneyama, Hideki Nakamura, Naoko Hattori …

Cell Reports Methods, 100052-100052, Jul, 2021 Peer-reviewed
Starvation‐induced transcription factor CREBH negatively governs body growth by controlling GH signaling

Yoshimi Nakagawa, Kae Kumagai, Song‐iee Han, Yuhei Mizunoe, Masaya Araki, Seiya Mizuno, Hiroshi Ohno, Kazuya Matsuo, Yasunari Yamada, Jun‐dal Kim …

The FASEB Journal, 35(6) e21663, Jun, 2021 Peer-reviewed
Enterohepatic Transcription Factor CREB3L3 Protects Atherosclerosis via SREBP Competitive Inhibition

Yoshimi Nakagawa, Yunong Wang, Song-Iee Han, Kanako Okuda, Asayo Oishi, Yuka Yagishita, Kae Kumagai, Hiroshi Ohno, Yoshinori Osaki, Yuhei Mizunoe …

Cellular and Molecular Gastroenterology and Hepatology, 11(4) 949-971, 2021 Peer-reviewed
肝臓特異的Elovl6欠損マウスの肝臓ではC18-ceramideが減少することによりインスリン感受性が亢進する

松坂賢, 久芳素子, 小安さおり, 本村香織, 大野博, Rahul Sharma, 武内謙憲, 矢作直也, 宮本崇史, 関谷元博 …

日本内分泌学会雑誌, 96(1) 256-256, Aug, 2020
肝臓特異的Elovl6欠損マウスの肝臓ではC18-ceramideが減少することによりインスリン感受性が亢進する

松坂賢, 久芳素子, 小安さおり, 本村香織, 大野博, Rahul Sharma, 武内謙憲, 矢作直也, 宮本崇史, 関谷元博 …

糖尿病, 63(Suppl.1) S-227, Aug, 2020
CREBH Improves Diet-Induced Obesity, Insulin Resistance, and Metabolic Disturbances by FGF21-Dependent and FGF21-Independent Mechanisms.

Aoi Satoh, Song-Iee Han, Masaya Araki, Yoshimi Nakagawa, Hiroshi Ohno, Yuhei Mizunoe, Kae Kumagai, Yuki Murayama, Yoshinori Osaki, Hitoshi Iwasaki …

iScience, 23(3) 100930-100930, Feb 21, 2020 Peer-reviewed
Hepatocyte Elovl6 Determines Ceramide Acyl-Chain Length and Hepatic Insulin Sensitivity in Mice

Takashi Matsuzaka, Motoko Kuba, Saori Koyasu, Yuta Yamamoto, Kaori Motomura, Sundaram Arulmozhiraja, Hiroshi Ohno, Rahul Sharma, Takuya Shimura, Yuka Okajima …

Hepatology, Sep, 2019 Peer-reviewed
Octacosanol and policosanol prevent high-fat diet-induced obesity and metabolic disorders by activating brown adipose tissue and improving liver metabolism.

Sharma R, Matsuzaka T, Kaushik MK, Sugasawa T, Ohno H, Wang Y, Motomura K, Shimura T, Okajima Y, Mizunoe Y …

Scientific Reports, 9(1) 5169-5169, Mar, 2019 Peer-reviewed
The Peroxisome Proliferator-Activated Receptor α (PPARα) Agonist Pemafibrate Protects against Diet-Induced Obesity in Mice.

Araki M, Nakagawa Y, Oishi A, Han SI, Wang Y, Kumagai K, Ohno H, Mizunoe Y, Iwasaki H, Sekiya M …

International Journal of Molecular Sciences, 19(7) E2148, Jul, 2018 Peer-reviewed
Transgenic Mice Overexpressing SREBP-1a in Male ob/ob Mice Exhibit Lipodystrophy and Exacerbate Insulin Resistance

Hiroshi Ohno, Takashi Matsuzaka, Nie Tang, Rahul Sharma, Kaori Motomura, Takuya Shimura, Aoi Satoh, Song-Iee Han, Yoshinori Takeuchi, Yuichi Aita …

Endocrinology, 159(6) 2308-2323, Jun 1, 2018 Peer-reviewed
Selective peroxisome proliferator-activated receptor-α modulator K-877 efficiently activates the peroxisome proliferator-activated receptor-α pathway and improves lipid metabolism in mice.

Takei K, Han SI, Murayama Y, Satoh A, Oikawa F, Ohno H, Osaki Y, Matsuzaka T, Sekiya M, Iwasaki H …

Journal of Diabetes Investigation, 8(4) 446-452, Apr, 2017 Peer-reviewed
Different Effects of Eicosapentaenoic and Docosahexaenoic Acids on Atherogenic High-Fat Diet-Induced Non-Alcoholic Fatty Liver Disease in Mice

Noriko Suzuki-Kemuriyama, Takashi Matsuzaka, Motoko Kuba, Hiroshi Ohno, Song-iee Han, Yoshinori Takeuchi, Masaaki Isaka, Kazuto Kobayashi, Hitoshi Iwasaki, Shigeru Yatoh …

PLOS ONE, 11(6) e0157580, Jun, 2016 Peer-reviewed
Hyperlipidemia and hepatitis in liver-specific CREB3L3 knockout mice generated using a one-step CRISPR/Cas9 system

Yoshimi Nakagawa, Fusaka Oikawa, Seiya Mizuno, Hiroshi Ohno, Yuka Yagishita, Aoi Satoh, Yoshinori Osaki, Kenta Takei, Takuya Kikuchi, Song-iee Han …

SCIENTIFIC REPORTS, 6 27857, Jun, 2016 Peer-reviewed
Absence of Elovl6 attenuates steatohepatitis but promotes gallstone formation in a lithogenic diet-fed Ldlr(-/-) mouse model

Motoko Kuba, Takashi Matsuzaka, Rie Matsumori, Ryo Saito, Naoko Kaga, Hikari Taka, Kei Ikehata, Naduki Okada, Takuya Kikuchi, Hiroshi Ohno …

SCIENTIFIC REPORTS, 5 17604, Dec, 2015 Peer-reviewed

Misc.

ob/obマウスにおけるSREBP-1a過剰発現はリポジストロフィーとインスリン抵抗性の増悪を示す

大野博, 松坂賢, 唐ネ, Rahul Sharma, 本村香織, 志村拓哉, 佐藤葵, 鈴木浩明, 関谷元博, 中川嘉 …

肥満研究, 24(Suppl.) 179-179, Sep, 2018

Presentations

神経幹細胞の自己複製能および分化能における脂肪酸伸長酵素Elovl6の役割の解明

大野博, 松坂賢, 林昭夫, 島野仁

第64回日本脂質生化学大会, Jun 23, 2022
脂肪酸伸長酵素Elovl6による神経幹細胞の自己複製能制御機構解明

大野博, 松坂賢, 本村香織, 志村拓哉, 水之江雄平, 宮本崇史, 関谷元博, 中川嘉, 林昭夫, 島野仁

第94回日本生化学大会, Nov 3, 2021
ob/obマウスにおけるSREBP-1a過剰発現はリポジストロフィーとインスリン抵抗性の増悪を示す

大野博, 松坂賢, 唐ネ, Sharma Rahul, 本村香織, 志村拓哉, 佐藤葵, 鈴木浩明, 関谷元博, 中川嘉, 曽根博仁, 矢作直也, 樋上賀一, 山田信博, 島野仁

第39回日本肥満学会, Oct 7, 2018
脳における脂肪酸伸長酵素Elovl6 の役割

大野博, 松坂賢, 吉田恵里子, 伏見友希, 所司慶太, 中川嘉, 矢作直也, 山田信博, 島野仁

第88回日本内分泌学会, Apr 25, 2015
脂質合成制御転写因子SREBP-1a トランスジェニックマウスの脂肪萎縮機序とそのエネルギー代謝におよぼす影響

大野博, 松坂賢, 唐ネ, 中川嘉, 嶋田昌子, 岩﨑仁, 小林和人, 高橋昭光, 矢藤繁, 矢作直也, 鈴木浩明, 山田信博, 島野仁

第57回日本糖尿病学会, May 23, 2014

Professional Memberships

Research Projects

Fatty acid diversity and its sensing mechanism for metabolic control and therapeutic application

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (A), Japan Society for the Promotion of Science, Apr, 2022 - Mar, 2025
脂肪酸による新規ミトコンドリア機能制御機構の解明と生活習慣病の予防・治療への応用

科学研究費助成事業, 基盤研究(B), 日本学術振興会, Apr, 2021 - Mar, 2024

松坂賢, 大野博
脂肪酸の質的変容によるニューロン機能の制御機構解明と神経変性疾患治療への応用

科学研究費助成事業, 若手研究, 日本学術振興会, Apr, 2022 - Mar, 2024

大野博
スフィンゴ脂質の脂肪酸組成制御による神経幹細胞の自己複製能制御機構解明

小野医学研究奨励助成, 公益財団法人小野医学研究財団, Apr, 2021 - Mar, 2022

大野博
Elucidation of the molecular basis of neurogenesis by regulation of fatty acid composition

Grants-in-Aid for Scientific Research Grant-in-Aid for Early-Career Scientists, Grant-in-Aid for Early-Career Scientists, Japan Society for the Promotion of Science, Apr, 2020 - Mar, 2022

OHNO Hiroshi
脂肪酸伸長酵素Elovl6による神経新生制御機構解明

研究奨励金, 上原記念生命科学財団, 2020

大野博
脂肪酸組成制御が高次脳機能と精神疾患におよぼす影響の解明と健康科学への応用

特別研究員奨励費, 日本学術振興会, Apr, 2016 - Mar, 2019

大野博

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