論文

査読有り
2017年

Sasa veitchii extracts suppress acetaminophen-induced hepatotoxicity in mice

ENVIRONMENTAL HEALTH AND PREVENTIVE MEDICINE
  • Hiroki Yoshioka
  • ,
  • Haruki Usuda
  • ,
  • Hirohisa Fujii
  • ,
  • Tsunemasa Nonogaki

22
1
開始ページ
54
終了ページ
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1186/s12199-017-0662-3
出版者・発行元
SPRINGER

Background: The aim of this study was to investigate the therapeutic effects of a Sasa veitchii leaf extract (SE) on acetaminophen (APAP)-induced hepatotoxicity.
Methods: Seven-week-old male ddY mice were orally administered SE or saline (0.2 mL) once a day for a week. Twenty-four hours after the last pretreatment, the mice were intraperitoneally injected with 550 mg/kg APAP or saline under fasting conditions. The mice from each group were euthanized and bled for plasma analysis 2, 6, 24, and 72 h after the injection.
Results: We found that pretreatment with SE significantly decreased hepatic injury markers (i.e., alanine aminotransferase and aspartate aminotransferase), oxidative stress (malondialdehyde and glutathione level), inflammatory cytokines, histological damage, c-jun N-terminal kinase activation, and receptor-interacting protein-1 activation. Further, SE pretreatment decreased Cyp2e1 expression and increased total antioxidant capacity in the liver.
Conclusion: Our findings demonstrate that prophylactic SE treatment protects mice from APAP-induced hepatotoxicity through modulation of Cyp2e1 expression and antioxidant capacity.

Web of Science ® 被引用回数 : 5

リンク情報
DOI
https://doi.org/10.1186/s12199-017-0662-3
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/29165178
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000404739400009&DestApp=WOS_CPL