Haruki Usuda

Profile Information

Affiliation: Associate professor (Lecturer), Department of Pharmacology, Shimane University Faculty of Medicine

Degree: Pharmaceutical Sciences(Mar, 2012, Gifu University)

J-GLOBAL ID: 201701014378024031
researchmap Member ID: B000282115

External link: https://www.med.shimane-u.ac.jp/pharmacology/index.html

Research Interests

Research Areas

Research History

Apr, 2024 - Present

Assosiate Professor (Lecturer), Department of Pharmacology, Faculty of Medicine, Shimane University
Apr, 2015 - Present

Assistant Professor, Department of Pharmacology, Faculty of Medicine, Shimane University
Apr, 2013 - Mar, 2015

Assistant Professor, Faculty of Pharmacy, Kinjogakuin Univ

Awards

Apr, 2023

Leave a Nest NH Foods Prize in 2022, NH Foods Ltd.
Nov, 2007

実行委員長賞, 日本薬学会（環境衛生部会）

臼田春樹

Papers

Combined, elobixibat, and colestyramine reduced cholesterol toxicity in a mouse model of metabolic dysfunction-associated steatotic liver disease.

Michihiro Iwaki, Takaomi Kessoku, Kosuke Tanaka, Anna Ozaki, Yuki Kasai, Takashi Kobayashi, Asako Nogami, Yasushi Honda, Yuji Ogawa, Kento Imajo …

Hepatology communications, 7(11), Nov 1, 2023
PERIODONTAL TREATMENT AND USUAL CARE FOR NON-ALCOHOLIC FATTY LIVER DISEASE: A MULTICENTER, RANDOMIZED CONTROLLED TRIAL.

Yohei Kamata, Takaomi Kessoku, Tomoko Shimizu, Satsuki Sato, Takashi Kobayashi, Takeo Kurihashi, Toshiya Morozumi, Tomoyuki Iwasaki, Shogo Takashiba, Kazu Hatanaka …

Clinical and translational gastroenterology, 13(11) e00520, Aug 23, 2022
A cross-sectional study assessing the relationship between non-alcoholic fatty liver disease and periodontal disease

Satsuki Sato, Yohei Kamata, Takaomi Kessoku, Tomoko Shimizu, Takashi Kobayashi, Takeo Kurihashi, Shogo Takashiba, Kazu Hatanaka, Nobushiro Hamada, Toshiro Kodama …

Scientific Reports, 12(1), Aug 10, 2022
MiR-126-3p and MiR-199a-3p Promote Lipid Accumulation in 3T3-L1 Adipocytes via Regulating HIF-1α and C/EBPα Expression

JAHAN Israt, OKAMOTO Takayuki, USUDA Haruki, TANAKA Tetsuya, NIIBAYASHI Tomomi, NAKAJIMA Atsushi, WADA Koichiro

Shimane Journal of Medical Science (Web), 39(4), Jul, 2022
Association of Serum and Fecal Bile Acid Patterns With Liver Fibrosis in Biopsy-Proven Nonalcoholic Fatty Liver Disease: An Observational Study.

Yuki Kasai, Takaomi Kessoku, Kosuke Tanaka, Atsushi Yamamoto, Kota Takahashi, Takashi Kobayashi, Michihiro Iwaki, Anna Ozaki, Asako Nogami, Yasushi Honda …

Clinical and translational gastroenterology, 13(7) e00503, Jul 1, 2022
A prospective interventional trial on the effect of periodontal treatment on Fusobacterium nucleatum abundance in patients with colorectal tumours.

Tsutomu Yoshihara, Mitomu Kioi, Junichi Baba, Haruki Usuda, Takaomi Kessoku, Michihiro Iwaki, Tomohiro Takatsu, Noboru Misawa, Keiichi Ashikari, Tetsuya Matsuura …

Scientific reports, 11(1) 23719-23719, Dec 9, 2021
Juvenile social defeat stress exposure favors in later onset of irritable bowel syndrome-like symptoms in male mice.

Kenjiro Matsumoto, Kana Takata, Daisuke Yamada, Haruki Usuda, Koichiro Wada, Maaya Tada, Yoshiyuki Mishima, Shunji Ishihara, Syunji Horie, Akiyoshi Saitoh …

Scientific reports, 11(1) 16276-16276, Aug 11, 2021
Endothelial connexin-integrin crosstalk in vascular inflammation.

Haruki Usuda

Biochimica et biophysica acta. Molecular basis of disease, 166168, May 13, 2021 Peer-reviewedInvited
歯周病治療が与える便や大腸腫瘍のF.nucleatumへの影響

吉原努, 日暮琢磨, 中島淳, 高津智弘, 三澤昇, 芦苅圭一, 大久保秀則, 馬場隼一, 來生知, 臼田春樹 …

日本消化器病学会雑誌, 118(臨増総会) A417-A417, Mar, 2021
Gut microbiota composition associated with hepatic fibrosis in non-obese patients with non-alcoholic fatty liver disease

Michihiro Iwaki, Takaomi Kessoku, Anna Ozaki, Yuki Kasai, Takashi Kobayashi, Asako Nogami, Yasushi Honda, Yuji Ogawa, Kento Imajo, Masato Yoneda …

JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, 36(8) 2275-2284, Mar, 2021
Endothelial connexin-integrin crosstalk in vascular inflammation

Okamoto Takayuki, Park Eun Jeong, Kawamoto Eiji, Kawamoto Eiji, Usuda Haruki, Wada Koichiro, Taguchi Akihiko, Shimaoka Motomu

Biochimica et Biophysica Acta, 1867(9), 2021
Efficacy of Bifidobacterium bifidum G9-1 in improving quality of life in patients with chronic constipation: a prospective intervention study

Akiko Fuyuki, Takuma Higurashi, Takaomi Kessoku, Keiichi Ashikari, Tsutomu Yoshihara, Noboru Misawa, Michihiro Iwaki, Takashi Kobayashi, Hidenori Ohkubo, Masato Yoneda …

BIOSCIENCE OF MICROBIOTA FOOD AND HEALTH, 40(2) 105-114, 2021
Lubiprostone in patients with non-alcoholic fatty liver disease: a randomised, double-blind, placebo-controlled, phase 2a trial

Takaomi Kessoku, Kento Imajo, Takashi Kobayashi, Anna Ozaki, Michihiro Iwaki, Yasushi Honda, Takayuki Kato, Yuji Ogawa, Wataru Tomeno, Shingo Kato …

LANCET GASTROENTEROLOGY & HEPATOLOGY, 5(11) 996-1007, Nov, 2020
Efficacy and safety of PERIOdontal treatment versus usual care for Nonalcoholic liver disease: protocol of the PERION multicenter, two-arm, open-label, randomized trial

Yohei Kamata, Takaomi Kessoku, Tomoko Shimizu, Takashi Kobayashi, Takeo Kurihashi, Satsuki Sato, Syotaro Kuraji, Norio Aoyama, Tomoyuki Iwasaki, Shogo Takashiba …

TRIALS, 21(1) 291-291, Mar, 2020
Recombinant Human Soluble Thrombomodulin Suppresses Monocyte Adhesion by Reducing Lipopolysaccharide-Induced Endothelial Cellular Stiffening

Okamoto Takayuki, Kawamoto Eiji, Kawamoto Eiji, Usuda Haruki, Tanaka Tetsuya, Tanaka Tetsuya, Nikai Tetsuro, Asanuma Kunihiro, Suzuki Koji, Shimaoka Motomu …

Cells (Web), 9(8), 2020
Differential Expression of Pro-inflammatory and Pro-coagulant Genes in Endothelial Cells Induced by Porphyromonas gingivalis Lipopolysaccharide, Escherichia coli Lipopolysaccharide, and Zymosan

HOSSAIN Kazi Helal, OKAMOTO Takayuki, USUDA Haruki, JAHAN Israt, NIIBAYASHI Tomomi, WADA Koichiro

Shimane Journal of Medical Science, 37(4), 2020
Rationale and design of a randomised, double-blind, placebo-controlled, parallel-group, investigator-initiated phase 2a study to investigate the efficacy and safety of elobixibat in combination with cholestyramine for non-alcoholic fatty liver disease

Takaomi Kessoku, Takashi Kobayashi, Anna Ozaki, Michihiro Iwaki, Yasushi Honda, Yuji Ogawa, Kento Imajo, Yusuke Saigusa, Koji Yamamoto, Takeharu Yamanaka …

BMJ OPEN, 10(9) e037961, 2020
The benefit of elobixibat in chronic constipation is associated with faecal deoxycholic acid but not effects of altered microbiota

Misawa Noboru, Higurashi Takuma, Takatsu Tomohiro, Iwaki Michihiro, Kobayashi Takashi, Yoshihara Tsutomu, Ashikari Keiichi, Kessoku Takaomi, Fuyuki Akiko, Matsuura Tetsuya …

Alimentary Pharmacology & Therapeutics, 52(5) 821-828, 2020 Peer-reviewed
Up-Regulated MicroRNA-27b Promotes Adipocyte Differentiation via Induction of Acyl-CoA Thioesterase 2 Expression

Murata Yuka, Yamashiro Takashi, Kessoku Takaomi, Jahan Israt, Usuda Haruki, Tanaka Tetsuya, Okamoto Takayuki, Nakajima Atsushi, Wada Koichiro

BioMed Research International (Web), 2019 2916243-2916243, 2019 Peer-reviewed
Reduced substrate stiffness promotes M2-like macrophage activation and enhances peroxisome proliferator-activated receptor γ expression

Okamoto Takayuki, Okamoto Takayuki, Takagi Yoshimi, Kawamoto Eiji, Kawamoto Eiji, Park Eun Jeong, Usuda Haruki, Wada Koichiro, Shimaoka Motomu

Experimental Cell Research, 367(2) 264-273, 2018 Peer-reviewed

Misc.

血管内皮細胞の硬さとギャップ結合におけるYAPの役割

岡本貴行, 臼田春樹, 和田孝一郎

日本薬理学雑誌, 158(Supplement), 2023
Patients with cardiovascular diseases exhibit distinct characteristics in their oral microbiome and are more susceptible to infections by pathogenic bacteria.

Usuda Haruki, Niibayashi Tomomi, Morita Yusuke, Endo Akihiro, Okamoto Takayuki, Tanabe Kazuaki, Wada Koichiro

Proceedings for Annual Meeting of The Japanese Pharmacological Society, 97 3-B-P-046, 2023
Hornerin expressed in endothelial cells implicates in angiogenesis

Okamoto Takayuki, Katsube Yukiko, Hattori Mai, Usuda Haruki, Ota Junichi, Nikai Tetsuro, Wada Koichiro

Proceedings for Annual Meeting of The Japanese Pharmacological Society, 97 3-B-O19-2, 2023
無症候性脳病変と口腔内細菌との関連性

加藤芳恵, 和田孝一郎, 臼田春樹, 高村真広, 安部哲史, 三瀧真悟, 長井篤

臨床神経学, 62(Suppl.) S274-S274, Oct, 2022
無症候性脳病変と口腔内細菌との関連性

加藤芳恵, 和田孝一郎, 臼田春樹, 高村真広, 安部哲史, 三瀧真悟, 長井篤

臨床神経学, 62(Suppl.) S274-S274, Oct, 2022
細胞外環境の硬さによる血管内皮細胞の機能変化

岡本貴行, 臼田春樹, 和田孝一郎

血管, 45(1) 55-55, Jun, 2022
好酸球性食道炎患者における高病原性口腔内細菌の保菌および口腔内細菌叢についての基礎的検討

臼田春樹, 新林友美, 岡本貴行, 和田孝一郎

日本薬理学雑誌, 157(Supplement), 2022
MiR-126-3p and MiR-199a-3p Promote Lipid Accumulation in 3T3-L1 Adipocytes via Regulating HIF-1α and C/EBPα Expression

WADA Koichiro, JAHAN Israt, OKAMOTO Takayuki, USUDA Haruki, TANAKA Tetsuya, NIIBAYASHI Tomomi, NAKAJIMA Atsushi

Shimane Journal of Medical Science, 39(4) 123-133, 2022
オンライン薬理学実習：シミュレーターを活用した薬理学実習・動物実習の有用性？

和田孝一郎, 臼田春樹, 岡本貴行, 新林友美

日本臨床薬理学会学術総会抄録集, 43 2-C-S23-3, 2022
Increased permeability of intestinal mucosa and multi-organ association: Leaky Gut Syndrome as a target for drug discovery.

Wada Koichiro, Usuda Haruki, Okamoto Takayuki, Niibayashi Tomomi

Proceedings for Annual Meeting of The Japanese Pharmacological Society, 95 1-S06-4, 2022
Oral microbiome in eosinophilic esophagitis

Usuda Haruki, Niibayashi Tomomi, Okamoto Takayuki, Wada Koichiro

Proceedings for Annual Meeting of The Japanese Pharmacological Society, 95 2-O-095, 2022
Extracellular substrate stiffness-mediated regulation of endothelial cell function

Okamoto Takayuki, Usuda Haruki, Wada Koichiro

Proceedings for Annual Meeting of The Japanese Pharmacological Society, 95 2-O-101, 2022
食物繊維の欠乏が大腸炎モデルマウスに与える影響

神田翔磨, 臼田春樹, 狩野園子, 岡本貴行, 新林友美, 矢野貴久, 直良浩司, 和田孝一郎

日本臨床薬理学会学術総会抄録集, 43 3-C-O09-3, 2022
食物繊維摂取欠乏が肝臓の脂肪蓄積へ及ぼす影響

狩野園子, 臼田春樹, 神田翔磨, 岡本貴行, 新林友美, 矢野貴久, 直良浩司, 和田孝一郎

日本臨床薬理学会学術総会抄録集, 43 2-C-P-086, 2022
Up-regulated miR-199a-3p and miR-126-3p promote adipocyte differentiation by targeting HIF-1α

Jahan Israt, Okamoto Takayuki, Usuda Haruki, Tanaka Tetsuya, Nakajima Atsushi, Wada Koichiro

Proceedings for Annual Meeting of The Japanese Pharmacological Society, 95 2-P-178, 2022
The Role of Leaky Gut in Nonalcoholic Fatty Liver Disease: A Novel Therapeutic Target.

Takaomi Kessoku, Takashi Kobayashi, Kosuke Tanaka, Atsushi Yamamoto, Kota Takahashi, Michihiro Iwaki, Anna Ozaki, Yuki Kasai, Asako Nogami, Yasushi Honda …

International journal of molecular sciences, 22(15), Jul 29, 2021
Leaky Gut: Effect of Dietary Fiber and Fats on Microbiome and Intestinal Barrier

Haruki Usuda, Takayuki Okamoto, Koichiro Wada

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 22(14), Jul, 2021
歯周病治療が与える便や大腸腫瘍のF.nucleatumへの影響

吉原努, 日暮琢磨, 中島淳, 高津智弘, 三澤昇, 芦苅圭一, 大久保秀則, 馬場隼一, 來生知, 臼田春樹 …

日本消化器病学会雑誌, 118(臨増総会) A417-A417, Mar, 2021
Endotoxins and Non-Alcoholic Fatty Liver Disease.

Takaomi Kessoku, Takashi Kobayashi, Kento Imajo, Kosuke Tanaka, Atsushi Yamamoto, Kota Takahashi, Yuki Kasai, Anna Ozaki, Michihiro Iwaki, Asako Nogami …

Frontiers in endocrinology, 12 770986-770986, 2021
Treatment of periodontal disease reduces Fusobacterium nucleatum in feces

吉原努, 日暮琢磨, 高津智弘, 三澤昇, 芦苅圭一, 松浦哲也, 冬木晶子, 大久保秀則, 馬場隼一, 來生知 …

日本消化管学会雑誌, 5(Supplement) 171-171, 2021

Research Projects

食物繊維の欠損が腸のバリア機能および肝臓の脂肪蓄積に及ぼす影響についての検討

科学研究費助成事業基盤研究(C), 基盤研究(C), 日本学術振興会, Apr, 2023 - Mar, 2026

臼田春樹
Correlationship between oral bacteria and cardiovascular diseases

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2022 - Mar, 2025
A challenge study to establish early diagnosis method for inflammatory bowel diseases by utilizing revolutionary quantifying method for intestinal barrier function

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2020 - Mar, 2023
Development of a prediction system of systemic disease using AI technology based on oral flora.

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, Apr, 2019 - Mar, 2022

WADA Koichiro
A research for investigating the mechanism how highly pathogenic oral bacteria induces eosinophilic esophagitis.

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2019 - Mar, 2022

Niibayashi Tomomi
Can NASH be induced by leaky gut syndrome ?

Grants-in-Aid for Scientific Research Grant-in-Aid for Early-Career Scientists, Grant-in-Aid for Early-Career Scientists, Japan Society for the Promotion of Science, Apr, 2018 - Mar, 2020

Ususa Haruki
Clinical study of examining relation of oral bacteria and fundus bleeding

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2017 - Mar, 2020

Hara Katsunori
The role of gap junction-mediated regulation of endothelial cellular stiffness

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2016 - Mar, 2019

Okamoto Takayuki, Suzuki Koji, Shimaoka Motomu, Kawamoto Eiji, Niibayashi Tomomi, Usuda Haruki, Tanaka Tetsuya, Wada Koichiro
Establishment of diagnostic method for leaky gut syndrome using mice model.

Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B), Grant-in-Aid for Young Scientists (B), Japan Society for the Promotion of Science, Apr, 2016 - Mar, 2018

Usuda Haruki, WADA KOICHIRO, OKAMOTO TAKAYUKI, TANAKA TETSUYA, NIIBAYASHI TOMOMI

Industrial Property Rights

特許第6782886号腸粘膜の透過性の診断薬、診断方法、診断装置

和田孝一郎, 臼田春樹, 中村守彦, 高森吉守, 黒住誠司

Profile Information

Research Interests

Research Areas

Research History

Awards

Papers

Misc.

Research Projects

Industrial Property Rights

Menu

Coauthors