2021年3月5日
Regulation of Neutrophil Functions by Hv1/VSOP Voltage-Gated Proton Channels
International Journal of Molecular Sciences
- ,
- 巻
- 22
- 号
- 5
- 開始ページ
- 2620
- 終了ページ
- 2620
- 記述言語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.3390/ijms22052620
- 出版者・発行元
- MDPI AG
The voltage-gated proton channel, Hv1, also termed VSOP, was discovered in 2006. It has long been suggested that proton transport through voltage-gated proton channels regulate reactive oxygen species (ROS) production in phagocytes by counteracting the charge imbalance caused by the activation of NADPH oxidase. Discovery of Hv1/VSOP not only confirmed this process in phagocytes, but also led to the elucidation of novel functions in phagocytes. The compensation of charge by Hv1/VSOP sustains ROS production and is also crucial for promoting Ca2+ influx at the plasma membrane. In addition, proton extrusion into neutrophil phagosomes by Hv1/VSOP is necessary to maintain neutral phagosomal pH for the effective killing of bacteria. Contrary to the function of Hv1/VSOP as a positive regulator for ROS generation, it has been revealed that Hv1/VSOP also acts to inhibit ROS production in neutrophils. Hv1/VSOP inhibits hypochlorous acid production by regulating degranulation, leading to reduced inflammation upon fungal infection, and suppresses the activation of extracellular signal-regulated kinase (ERK) signaling by inhibiting ROS production. Thus, Hv1/VSOP is a two-way player regulating ROS production. Here, we review the functions of Hv1/VSOP in neutrophils and discuss future perspectives.
- ID情報
-
- DOI : 10.3390/ijms22052620
- eISSN : 1422-0067