2017年12月1日
A view of the therapy for bell’s palsy based on molecular biological analyses of facial muscles
Journal of International Advanced Otology
- ,
- ,
- ,
- 巻
- 13
- 号
- 3
- 開始ページ
- 414
- 終了ページ
- 416
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.5152/iao.2017.3971
- 出版者・発行元
- Mediterranean Society of Otology and Audiology
OBJECTIVE: Details regarding the molecular biological features of Bell’s palsy have not been widely reported in textbooks. We genetically analyzed facial muscles and clarified these points. MATERIALS and METHODS: We performed genetic analysis of facial muscle specimens from Japanese patients with severe (House-Brackmann facial nerve grading system V) and moderate (House-Brackmann facial nerve grading system III) dysfunction due to Bell’s palsy. Microarray analysis of gene expression was performed using specimens from the healthy and affected sides, and gene expression was compared. Changes in gene expression were defined as an affected side/healthy side ratio of >
1.5 or <
0.5. RESULTS: We observed that the gene expression in Bell’s palsy changes with the degree of facial nerve palsy. Especially, muscle, neuron, and energy category genes tended to fluctuate with the degree of facial nerve palsy. CONCLUSION: It is expected that this study will aid in the development of new treatments and diagnostic/prognostic markers based on the severity of facial nerve palsy.
1.5 or <
0.5. RESULTS: We observed that the gene expression in Bell’s palsy changes with the degree of facial nerve palsy. Especially, muscle, neuron, and energy category genes tended to fluctuate with the degree of facial nerve palsy. CONCLUSION: It is expected that this study will aid in the development of new treatments and diagnostic/prognostic markers based on the severity of facial nerve palsy.
- ID情報
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- DOI : 10.5152/iao.2017.3971
- ISSN : 2148-3817
- ISSN : 1308-7649
- PubMed ID : 29283103
- SCOPUS ID : 85041126080