MISC

査読有り 国際誌
2019年6月

Relationships between Alcohol Intake and Ischemic Stroke Severity in Sex Stratified Analysis for Japanese Acute Stroke Patients.

Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association
  • Hiroyuki Shiotsuki
  • ,
  • Yasuaki Saijo
  • ,
  • Yoichi Ogushi
  • ,
  • Shotai Kobayashi

担当区分
筆頭著者, 責任著者
28
6
開始ページ
1604
終了ページ
1617
記述言語
英語
掲載種別
DOI
10.1016/j.jstrokecerebrovasdis.2019.02.034

BACKGROUND: The aim of this study is to evaluate in the relationships between alcohol intake and ischemic stroke severity in Japanese stroke patients. METHODS: Of a total of 101,165 registered cases of stroke in Japan, patient data of total strokes (n = 60,836), cardiogenic strokes (n = 11,894), and noncardiogenic strokes (n = 29,129) were extracted. The National Institutes of Health Stroke Scale (NIHSS) score at admission and the modified Rankin Scale (mRS) score at discharge were used. Significant alcohol consumption in regard to stroke severity at admission and discharge was identified by multivariate adjusted logistic regression analysis. RESULTS: Among all subject and males, nondrinkers had significantly poorer NIHSS scores of cardiogenic strokes as did those consuming greater than or equal to 60 g/day, whereas there was a significant difference in past heavy drinkers with noncardiogenic strokes. Among females, nondrinkers had a significance of cardiogenic stroke and non-cardiogenic strokes. Among all subjects and males, 20-39 g/day and 40-59 g/day were significantly associated with protective effects on mRS severity of cardiogenic strokes, whereas 40-59 g/day also had significant protective effects for noncardiogenic strokes. Among females, greater than or equal to 60 g/day had a significant protective effect for cardiogenic strokes. CONCLUSIONS: For males, alcohol intake of less than 60 g/day played a protective role in functional prognosis at discharge and showed a J-shape relationship. For females, although there was a limitation that the number of female drinkers was small, negative effects were shown at admission with less consumption than males.

リンク情報
DOI
https://doi.org/10.1016/j.jstrokecerebrovasdis.2019.02.034
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/30904471

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