1995
The kinetics of induction of Hox1.6 and c-jun mRNA during three different ways of inducing differentiation in teratocarcinoma F9 cells
In Vitro Cellular & Developmental Biology - Animal: Journal of the Society for In Vitro Biology
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- Volume
- 31
- Number
- 6
- First page
- 462
- Last page
- 466
- Language
- English
- Publishing type
- Research paper (scientific journal)
- DOI
- 10.1007/BF02634259
Changes in Hox1.6 and c-jun gene expression were examined upon F9 cell differentiation that was induced by three independent methods: a drug treatment with retinoic acid (RA), that with sodium butyrate (NaB), and a genetic approach using the ts mutant. To obtain further information on the mechanism of teratocarcinoma cell differentiation we have examined the kinetics of the induction of Hox1.6 and c-jun mRNA whose gene products have been demonstrated to have specific roles in gene regulation. Expression of Hox1.6 mRNA was induced more rapidly than c-jun mRNA by all the above three inducing methods. Furthermore, protein synthesis was not required for the induction of Hox1.6 mRNA as well as of c-jun mRNA synthesis in all three methods. The data suggested that the transcriptional increase in the Hox1.6 mRNA was a primary response and could play an important role in F9 cell differentiation. © 1995, Society for In Vitro Biology. All rights reserved.
- Link information
- ID information
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- DOI : 10.1007/BF02634259
- ISSN : 1543-706X
- ISSN : 1071-2690
- Pubmed ID : 8589890
- SCOPUS ID : 0029014980
- Web of Science ID : WOS:A1995RG48300013