Papers

Peer-reviewed
Jan, 1995

INDUCTION OF TERATOCARCINOMA F9 CELL-DIFFERENTIATION WITH CIS-DIAMMINE DICHLOROPLATINUM(II) (CDDP)

CANCER LETTERS
  • T DOI
  • ,
  • T SUMI
  • ,
  • Y NISHINA
  • ,
  • M KOSAKA
  • ,
  • SA IWAI
  • ,
  • M SAKUDA
  • ,
  • Y NISHIMUNE

Volume
88
Number
1
First page
81
Last page
86
Language
English
Publishing type
Research paper (scientific journal)
Publisher
ELSEVIER SCI PUBL IRELAND LTD

cis-Diammine dichloroplatinum(II) (CDDP) is the salt of a platinum compound which has been noted to have a wide spectrum of activity against malignant disorders. We have studied the effects of CDDP on embryonal carcinoma F9 cell differentiation. In the presence of this agent in vitro, the cells showed rapid morphological changes, a marked increase in the mRNA expression of various differentiation markers accompanied by a loss of tumorigenicity. These results indicate that the differentiation of F9 cells is induced with CDDP.


Link information
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:A1995QG08800012&DestApp=WOS_CPL
ID information
  • ISSN : 0304-3835
  • Web of Science ID : WOS:A1995QG08800012

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