Apr, 1994
F9 cells can be differentiated toward 2 distinct, mutually exclusive pathways by Reitnoic acid and Sodium butyrate.
DEVELOPMENT GROWTH & DIFFERENTIATION
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- Volume
- 36
- Number
- 2
- First page
- 223
- Last page
- 230
- Language
- English
- Publishing type
- Research paper (scientific journal)
- DOI
- 10.1111/j.1440-169X.1994.00223.x
- Publisher
- BLACKWELL SCIENCE
Both retinoic acid (RA) and sodium butyrate (NaB) induce differentiation in embryonal carcinoma F9 cells. Phenotypic changes caused by RA are irreversible, whereas those of NaB are rapid and reversible. In this study, we investigated the effects of combinations of these two agents on F9 cell differentiation and showed that RA had no effect on the cells induced to differentiate with NaB and vice versa. Thus, F9 cells are induced to differentiate along two distinct pathways which are mutually exclusive.
- Link information
- ID information
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- DOI : 10.1111/j.1440-169X.1994.00223.x
- ISSN : 0012-1592
- Web of Science ID : WOS:A1994NU16200011