Papers

Peer-reviewed Lead author
Apr, 1994

F9 cells can be differentiated toward 2 distinct, mutually exclusive pathways by Reitnoic acid and Sodium butyrate.

DEVELOPMENT GROWTH & DIFFERENTIATION
  • M KOSAKA
  • ,
  • M TAKEDA
  • ,
  • K MATSUMOTO
  • ,
  • Y NISHIMUNE

Volume
36
Number
2
First page
223
Last page
230
Language
English
Publishing type
Research paper (scientific journal)
DOI
10.1111/j.1440-169X.1994.00223.x
Publisher
BLACKWELL SCIENCE

Both retinoic acid (RA) and sodium butyrate (NaB) induce differentiation in embryonal carcinoma F9 cells. Phenotypic changes caused by RA are irreversible, whereas those of NaB are rapid and reversible. In this study, we investigated the effects of combinations of these two agents on F9 cell differentiation and showed that RA had no effect on the cells induced to differentiate with NaB and vice versa. Thus, F9 cells are induced to differentiate along two distinct pathways which are mutually exclusive.


Link information
DOI
https://doi.org/10.1111/j.1440-169X.1994.00223.x
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:A1994NU16200011&DestApp=WOS_CPL
ID information
  • DOI : 10.1111/j.1440-169X.1994.00223.x
  • ISSN : 0012-1592
  • Web of Science ID : WOS:A1994NU16200011

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