Papers

Peer-reviewed
1993

Suppression of tumorigenicity in temperature‐sensitive mutants of embryonal carcinoma cells by induction of cell differentiation at non‐permissive temperature

International Journal of Cancer
  • Tetsuro Sumi
  • ,
  • Masayoshi Sakuda
  • ,
  • Yukio Nishina
  • ,
  • Mitsuko Kosaka
  • ,
  • Yoshitakc Nishimune

Volume
54
Number
2
First page
333
Last page
337
Language
English
Publishing type
Research paper (scientific journal)
DOI
10.1002/ijc.2910540228

The temperature‐sensitive (ts) mutants of cell differentiation derived from the mouse teratocarcinoma cell line F9, when exposed to non‐permissive temperature, undergo stem‐cell differentiation concomitant with a transient retardation of cell‐cycle progression. By incubating these mutant strains at non‐permissive temperature, we were able to study the relationship between cell differentiation and tumorigenicity. Upon exposure to non‐permissive temperature, the mutant cells undergo extensive differentiation and lose their ability to initiate tumors in vivo, but retain their in vitro proliferative potential. Our data suggest that the loss of tumorigenicity is not caused by altered proliferative potential, but rather by cell differentiation. We therefore suggest that the loss of proliferative potential and the onset of cell differentiation in teratocarcinoma F9 cells are 2 independent events which can be genetically dissected, and that there is (a) crucial step(s) in the differentiation pathway at which these ts mutant cells lose their tumorigenicity. Copyright © 1993 Wiley‐Liss, Inc., A Wiley Company


Link information
DOI
https://doi.org/10.1002/ijc.2910540228
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/8486432
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:A1993LB68800027&DestApp=WOS_CPL
ID information
  • DOI : 10.1002/ijc.2910540228
  • ISSN : 1097-0215
  • ISSN : 0020-7136
  • Pubmed ID : 8486432
  • SCOPUS ID : 0027298019
  • Web of Science ID : WOS:A1993LB68800027

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