1993
Changes in Hox1.6, c-jun, and Oct-3 gene expressions are associated with teratocarcinoma F9 cell differentiation in three different ways of induction
Experimental Cell Research
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- Volume
- 205
- Number
- 1
- First page
- 39
- Last page
- 43
- Language
- English
- Publishing type
- Research paper (scientific journal)
- DOI
- 10.1006/excr.1993.1055
To obtain information on the mechanism of teratocarcinoma cell differentiation, the expression of genes having a specific role in gene regulation was examined using three different methods of inducing differentiation: Drug treatments with retinoic acid (RA) and sodium butyrate, and a genetic approach using ts mutants. The RAR-β and MK genes were induced specifically by RA treatment, which indicates that these two genes are solely RA responsive. By contrast, a change in c-jun, Hox 1.6, and Oct-3 gene expression was observed in all three methods of F9 cell differentiation. These findings suggest that these three genes, whether down-or up-regulated, play an important and key role during teratocarcinoma cell differentiation. © 1993 Academic Press, Inc.
- Link information
- ID information
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- DOI : 10.1006/excr.1993.1055
- ISSN : 0014-4827
- Pubmed ID : 8453995
- SCOPUS ID : 0027318887
- Web of Science ID : WOS:A1993KT14700005