Papers

Peer-reviewed
1993

Changes in Hox1.6, c-jun, and Oct-3 gene expressions are associated with teratocarcinoma F9 cell differentiation in three different ways of induction

Experimental Cell Research
  • Souichi A. Iwai
  • ,
  • Mitsuko Kosaka
  • ,
  • Yukio Nishina
  • ,
  • Tetsuro Sumi
  • ,
  • Masayoshi Sakuda
  • ,
  • Yoshitake Nishimune

Volume
205
Number
1
First page
39
Last page
43
Language
English
Publishing type
Research paper (scientific journal)
DOI
10.1006/excr.1993.1055

To obtain information on the mechanism of teratocarcinoma cell differentiation, the expression of genes having a specific role in gene regulation was examined using three different methods of inducing differentiation: Drug treatments with retinoic acid (RA) and sodium butyrate, and a genetic approach using ts mutants. The RAR-β and MK genes were induced specifically by RA treatment, which indicates that these two genes are solely RA responsive. By contrast, a change in c-jun, Hox 1.6, and Oct-3 gene expression was observed in all three methods of F9 cell differentiation. These findings suggest that these three genes, whether down-or up-regulated, play an important and key role during teratocarcinoma cell differentiation. © 1993 Academic Press, Inc.


Link information
DOI
https://doi.org/10.1006/excr.1993.1055
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/8453995
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:A1993KT14700005&DestApp=WOS_CPL
ID information
  • DOI : 10.1006/excr.1993.1055
  • ISSN : 0014-4827
  • Pubmed ID : 8453995
  • SCOPUS ID : 0027318887
  • Web of Science ID : WOS:A1993KT14700005

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