Apr, 2019 - Mar, 2022
Elucidation and application of the regulatory mechanism of SPP1 gene in human cancer cells
Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)
- Grant number
- 19K09287
- Japan Grant Number (JGN)
- JP19K09287
- Grant amount
-
- (Total)
- 4,420,000 Japanese Yen
- (Direct funding)
- 3,400,000 Japanese Yen
- (Indirect funding)
- 1,020,000 Japanese Yen
We found that OCT4A and SPP1C are co-expressed in highly aggressive human breast, endometrial, and lung adenocarcinoma cell lines, but not in mesothelial tumour cell lines. Ablation of OCT4-positive cells in lung adenocarcinoma cells significantly decreased cell migration and SPP1C mRNA levels. The OCT4A/SPP1C axis was found in primary, early-stage, lung adenocarcinoma tumours.
- Link information
- ID information
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- Grant number : 19K09287
- Japan Grant Number (JGN) : JP19K09287