Apr, 2015 - Mar, 2017
Cellular plasticity of OCT4 expressing somatic cells
Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research Grant-in-Aid for Challenging Exploratory Research Grant-in-Aid for Challenging Exploratory Research
- Grant number
- 15K15016
- Japan Grant Number (JGN)
- JP15K15016
- Grant amount
-
- (Total)
- 3,770,000 Japanese Yen
- (Direct funding)
- 2,900,000 Japanese Yen
- (Indirect funding)
- 870,000 Japanese Yen
Oct4A, a POU-family transcription factor, is an indispensable and the preeminent pluripotency factor. However, whether Oct4 function in somatic tissues remains debated. Here we tried some useful systems to correctly understand somatic OCT4 gene function. Our findings open up the possibility again that OCT4 can be normal tissue stem cells and/or tumor initiating cells marker and could play a pivotal role in somatic tissues. In this study, we identified and characterized OCT4 transcripts and their translation products in human carcinoma cell lines.
- Link information
- ID information
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- Grant number : 15K15016
- Japan Grant Number (JGN) : JP15K15016