Research Projects

Apr, 2015 - Mar, 2017

Cellular plasticity of OCT4 expressing somatic cells

Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research Grant-in-Aid for Challenging Exploratory Research  Grant-in-Aid for Challenging Exploratory Research

Grant number
15K15016
Japan Grant Number (JGN)
JP15K15016
Grant amount
(Total)
3,770,000 Japanese Yen
(Direct funding)
2,900,000 Japanese Yen
(Indirect funding)
870,000 Japanese Yen

Oct4A, a POU-family transcription factor, is an indispensable and the preeminent pluripotency factor. However, whether Oct4 function in somatic tissues remains debated. Here we tried some useful systems to correctly understand somatic OCT4 gene function. Our findings open up the possibility again that OCT4 can be normal tissue stem cells and/or tumor initiating cells marker and could play a pivotal role in somatic tissues. In this study, we identified and characterized OCT4 transcripts and their translation products in human carcinoma cell lines.

Link information
URL
https://kaken.nii.ac.jp/file/KAKENHI-PROJECT-15K15016/15K15016seika.pdf
KAKEN
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15K15016
ID information
  • Grant number : 15K15016
  • Japan Grant Number (JGN) : JP15K15016