2011 - 2013
Role of Oct3/4 in retinal development and dieseases
Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C) Grant-in-Aid for Scientific Research (C)
- Grant number
- 23592606
- Japan Grant Number (JGN)
- JP23592606
- Grant amount
-
- (Total)
- 5,460,000 Japanese Yen
- (Direct funding)
- 4,200,000 Japanese Yen
- (Indirect funding)
- 1,260,000 Japanese Yen
We tried to investigate roles of Oct3/4 gene during development of normal retina and retinal diseases including tumors. At the first step, we re-investigated Oct3/4 expression in mouse eye. We isolated a novel Oct3/4 variant from normal mouse retina, which is regulated under translational control. Using human retinoblastoma and other carcinoma cell lines, we tested the expression of Oct3/4 transcripts and identified a variety of novel ones. Our results showed the clear different pattern between mice and human Oct3/4 gene variants expression, providing available relevant information for understanding the function of Oct3/4 in somatic tissue.
- Link information
- ID information
-
- Grant number : 23592606
- Japan Grant Number (JGN) : JP23592606