2016年3月
Circadian Gene Circuitry Predicts Hyperactive Behavior in a Mood Disorder Mouse Model
Cell Reports
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- 巻
- 14
- 号
- 12
- 開始ページ
- 2784
- 終了ページ
- 2796
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1016/j.celrep.2016.02.067
- 出版者・発行元
- CELL PRESS
Bipolar disorder, also known as manic-depressive illness, causes swings in mood and activity levels at irregular intervals. Such changes are difficult to predict, and their molecular basis remains unknown. Here, we use infradian (longer than a day) cyclic activity levels in alpha CaMKII (Camk2a) mutant mice as a proxy for such mood-associated changes. We report that gene-expression patterns in the hippocampal dentate gyrus could retrospectively predict whether the mice were in a state of high or low locomotor activity (LA). Expression of a subset of circadian genes, as well as levels of cAMP and pCREB, possible upstream regulators of circadian genes, were correlated with LA states, suggesting that the intrinsic molecular circuitry changes concomitant with infradian oscillatory LA. Taken together, these findings shed light onto the molecular basis of how irregular biological rhythms and behavior are controlled by the brain.
- リンク情報
- ID情報
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- DOI : 10.1016/j.celrep.2016.02.067
- ISSN : 2211-1247
- PubMed ID : 27028761
- Web of Science ID : WOS:000372869300003