論文

査読有り 国際誌
2018年7月10日

Methotrexate-associated lymphoproliferative disorders with angioimmunoblastic T-cell lymphoma-like features accompanied by gamma-heavy chain disease in a patient with rheumatoid arthritis.

Pathology international
  • Junichi Kiyasu
  • ,
  • Fumiko Arakawa
  • ,
  • Shojiro Haji
  • ,
  • Yoshimichi Tachikawa
  • ,
  • Mariko Tsuda
  • ,
  • Yasuhiro Tsukamoto
  • ,
  • Motohiko Ikeda
  • ,
  • Hiroki Muta
  • ,
  • Takamitsu Matsushima
  • ,
  • Hiroaki Miyoshi
  • ,
  • Motoaki Shiratsuchi
  • ,
  • Yoshihiro Ogawa
  • ,
  • Kouichi Ohshima
  • ,
  • Yuji Yufu

記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1111/pin.12703

Although gamma heavy chain disease (γ-HCD) lesions occasionally morphologically resemble angioimmunoblastic T-cell lymphoma (AITL), no association has been described in detail due to the rarity of the disease. In this report, we present a rare manifestation of methotrexate (MTX)-associated lymphoproliferative disorders (LPDs) with AITL-like features accompanied by γ-HCD in a 75-year-old man with rheumatoid arthritis (RA). A biopsy specimen was evaluated using immunohistochemistry, clonal analyses of immunoglobulin VH and T-cell receptor γ gene rearrangements by polymerase chain reaction, and Sanger sequencing for confirmation of the structure of deleted γ-HCD clones. The histological features characterized by proliferation of CD4- and PD-1-positive medium-sized T cells and arborizing high endothelial venules together with numbers of small lymphocytes, eosinophils, plasma cells, and histiocytes in the background mimicked those of AITL, but did not completely fulfill the diagnostic criteria. Clonal analysis demonstrated that the specimen contained multiple LPDs of both B-cell and T-cell lineages. Sequence analysis confirmed the co-existence of a clone responsible for production of the abnormal heavy chain. This report provides new insights into the pathology of γ-HCD. Multiple host-derived factors (e.g., RA and/or use of MTX) may be responsible for the occurrence of LPDs of multiple lineages within a single lymph node.

リンク情報
DOI
https://doi.org/10.1111/pin.12703
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/29987858
ID情報
  • DOI : 10.1111/pin.12703
  • PubMed ID : 29987858

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