Shojiro Haji

Profile Information

Affiliation: Faculty of Medical Sciences, Kyushu University

Degree: M.D(Mar, 2023, Kyushu University)

Researcher number: 70883982
ORCID ID: https://orcid.org/0000-0003-3651-2836
J-GLOBAL ID: 202001010729854648
researchmap Member ID: R000008035

Research Interests

Research Areas

Life sciences / Hematology and oncology / 免疫学

Research History

Apr, 2023 - Present

Assistant Professor, Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University
Apr, 2020 - Mar, 2023

招聘教員, 分子免疫制御分野, 大阪大学微生物病研究所
Apr, 2020

助教, 内分泌代謝・糖尿病内科, 九州大学病院

Education

Mar, 2017 - Mar, 2020

Research Institute for Microbial Diseases, Osaka University
Apr, 2016 - Feb, 2017

Medical Institute of Bioregulation, Kyushu University
Apr, 2004 - Mar, 2010

Faculty of Medicine, Oita University

Awards

Oct, 2023

Clinical Investigator Award

Papers

Dectin-2 Deficiency Promotes Pro-inflammatory Cytokine Release from Macrophages and Impairs Insulin Secretion.

Masamichi Fujita, Takashi Miyazawa, Keiichiro Uchida, Naohiro Uchida, Shojiro Haji, Seiichi Yano, Norifusa Iwahashi, Tomomi Hatayama, Shunsuke Katsuhara, Shintaro Nakamura …

Endocrinology, Dec 1, 2023
Human Dectin-1 is O-glycosylated and serves as a ligand for C-type lectin receptor CLEC-2.

Shojiro Haji, Taiki Ito, Carla Guenther, Miyako Nakano, Takashi Shimizu, Daiki Mori, Yasunori Chiba, Masato Tanaka, Sushil K Mishra, Janet A Willment …

eLife, 11, Dec 8, 2022 Peer-reviewedLead author
Endothelial function testing before conditioning therapy is useful for predicting transplant-related complications after allogeneic hematopoietic cell transplantation.

Shojiro Haji, Motoaki Shiratsuchi, Akiko Takamatsu, Mariko Tsuda, Hiroki Muta, Toru Masuda, Yasuhiro Nakashima, Yoshihiro Ogawa

International journal of hematology, 117(3) 438-445, Nov 27, 2022 Peer-reviewedLead author
Identification of a drug-response gene in multiple myeloma through longitudinal single-cell transcriptome sequencing.

Toru Masuda, Shojiro Haji (equally contributed), Yasuhiro Nakashima, Mariko Tsuda, Daisaku Kimura, Akiko Takamatsu, Norifusa Iwahashi, Hironobu Umakoshi, Motoaki Shiratsuchi, Chie Kikutake …

iScience, 25(8) 104781-104781, Aug 19, 2022 Peer-reviewedLead author
Rapid decrease in eGFR with concomitant use of tyrosine kinase inhibitors and renin-aldosterone-angiotensin system inhibitors in patients with chronic myelogenous leukemia.

Mariko Tsuda, Akie Hirata, Shoji Tokunaga, Toru Masuda, Shojiro Haji, Daisaku Kimura, Chinatsu Nojiri, Yasuhiro Nakashima, Motoaki Shiratsuchi, Koji Kato …

International journal of hematology, 116(6) 863-870, Aug 6, 2022 Peer-reviewed
Circulating endothelial cells and endothelial progenitor cells as potential predictors of acute GVHD after allogeneic hematopoietic stem cell transplantation.

Akiko Takamatsu, Yasuhiro Nakashima, Shojiro Haji, Mariko Tsuda, Toru Masuda, Daisaku Kimura, Motoaki Shiratsuchi, Yoshihiro Ogawa

European journal of haematology, 109(2) 146-153, Apr 23, 2022 Peer-reviewed
治療後に前葉機能の改善を得た下垂体原発Burkittリンパ腫の一例

山下彩織, 坂本竜一, 白石弘樹, 甲斐田実里, 永井博史, 牟田宏樹, 土師正二郎, 松田やよい, 中嶋康博, 小川佳宏

日本内分泌学会雑誌, 97(2) 494-494, Oct, 2021
Helicobacter pylori metabolites exacerbate gastritis through C-type lectin receptors.

Masahiro Nagata, Kenji Toyonaga, Eri Ishikawa, Shojiro Haji, Nobuyuki Okahashi, Masatomo Takahashi, Yoshihiro Izumi, Akihiro Imamura, Koichi Takato, Hideharu Ishida …

The Journal of experimental medicine, 218(1), Jan 4, 2021 Peer-reviewed
Efficacy and Safety of the Modified EPOCH Regimen (Etoposide, Vincristine, Doxorubicin, Carboplatin, and Prednisolone) for Adult T-cell Leukemia/Lymphoma: A Multicenter Retrospective Study.

Yasuhiro Tsukamoto, Junichi Kiyasu, Ilseung Choi, Mitsuo Kozuru, Naokuni Uike, Hayato Utsunomiya, Akie Hirata, Eriko Fujioka, Hirofumi Ohno, Eriko Nakashima …

Clinical lymphoma, myeloma & leukemia, 20(7) e445-e453, Jul, 2020 Peer-reviewed
Acquired hemophilia A associated with autoimmune pancreatitis with serum IgG4 elevation.

Taisuke Narazaki, Shojiro Haji, Yasuhiro Nakashima, Yasuhiro Tsukamoto, Mariko Tsuda, Akiko Takamatsu, Hirofumi Ohno, Takamitsu Matsushima, Tomoko Matsumoto, Keiji Nogami …

International journal of hematology, 108(3) 335-338, Sep, 2018 Peer-reviewed
Methotrexate-associated lymphoproliferative disorders with angioimmunoblastic T-cell lymphoma-like features accompanied by gamma-heavy chain disease in a patient with rheumatoid arthritis.

Junichi Kiyasu, Fumiko Arakawa, Shojiro Haji, Yoshimichi Tachikawa, Mariko Tsuda, Yasuhiro Tsukamoto, Motohiko Ikeda, Hiroki Muta, Takamitsu Matsushima, Hiroaki Miyoshi …

Pathology international, Jul 10, 2018 Peer-reviewed
Achievement of disease control with donor-derived EB virus-specific cytotoxic T cells after allogeneic peripheral blood stem cell transplantation for aggressive NK-cell leukemia.

Shojiro Haji, Motoaki Shiratsuchi, Takamitsu Matsushima, Akiko Takamatsu, Mariko Tsuda, Yasuhiro Tsukamoto, Emi Tanaka, Hirofumi Ohno, Eriko Fujioka, Yuriko Ishikawa …

International journal of hematology, 105(4) 540-544, Apr, 2017 Peer-reviewedLead author
Spontaneous splenic rupture in a patient with light-chain deposition disease undergoing autologous peripheral blood stem cell transplantation.

Shojiro Haji, Junichi Kiyasu, Yoshimichi Tachikawa, Jiro Toyonaga, Motohiko Ikeda, Mariko Tsuda, Yasuhiro Tsukamoto, Mitsuo Kozuru, Yuji Yufu

[Rinsho ketsueki] The Japanese journal of clinical hematology, 57(6) 754-9, Jun, 2016 Peer-reviewedLead author
Administration of an anti-CC chemokine receptor 4 monoclonal antibody, mogamulizumab, before allogeneic bone marrow transplantation for adult T-cell leukemia/lymphoma.

S Haji, J Kiyasu, I Choi, Y Suehiro, K Toyoda, M Tsuda, A Takamatsu, Y Nakashima, H Miyoshi, M Shiratsuchi …

Bone marrow transplantation, 51(3) 432-4, Mar, 2016 Peer-reviewedLead author
臨牀研究アザシチジンが奏効し,食道/咽頭がんの再発に対して放射線治療が可能であった治療関連白血病/骨髄異形成症候群

津田麻理子, 安部康信, 土師正二郎

臨牀と研究, 92(3) 383-385, Mar, 2015 Peer-reviewed
リンパ形質細胞様形態を呈し低悪性度B細胞リンパ腫との鑑別を要したCD20陽性骨髄腫

土師正二郎, 安部康信, 津田麻理子, 豊田康祐, 崔日承, 末廣陽子, 白土基明, 喜安純一, 鵜池直邦

臨床血液, 56(3) 335-338, Mar, 2015 Peer-reviewedLead author
[CD20-positive plasma cell myeloma with lymphoplasmacytoid appearance mimicking low-grade B-cell lymphoma].

Shojiro Haji, Yasunobu Abe, Mariko Tsuda, Kosuke Toyoda, Ilseung Choi, Youko Suehiro, Motoaki Shiratsuchi, Junichi Kiyasu, Naokuni Uike

[Rinsho ketsueki] The Japanese journal of clinical hematology, 56(3) 335-8, Mar, 2015 Peer-reviewedLead author
Factors associated with effects of 90Y-ibritumomab tiuxetan in patients with relapsed or refractory low-grade B cell non-Hodgkin lymphoma: single-institution experience with 94 Japanese patients in rituximab era.

Naokuni Uike, Ilseung Choi, Mariko Tsuda, Shojirou Haji, Kousuke Toyoda, Youko Suehiro, Yasunobu Abe, Toshinobu Hayashi, Hirofumi Sawamoto, Koichiro Kaneko …

International journal of hematology, 100(4) 386-92, Oct, 2014 Peer-reviewed
リツキシマブ併用ソブゾキサンおよびエトポシドの経口少量療法が奏効した高齢者ヒトヘルペスウイルス8陰性Primary effusion lymphoma-like lymphoma

豊田康祐, 安部康信, 津田麻理子, 土師正二郎, 崔日承, 末廣陽子, 喜安純一, 大島孝一, 鵜池直邦

臨床血液, 55(7) 815-819, Jul, 2014 Peer-reviewed
[Successful treatment with oral low-dose sobuzoxane and etoposide combined with rituximab in an elderly patient with HHV-8-negative primary effusion lymphoma-like lymphoma].

Kosuke Toyoda, Yasunobu Abe, Mariko Tsuda, Shojiro Haji, Ilseung Choi, Youko Suehiro, Junichi Kiyasu, Koichi Ohshima, Naokuni Uike

[Rinsho ketsueki] The Japanese journal of clinical hematology, 55(7) 815-9, Jul, 2014 Peer-reviewed

Misc.

経時的一細胞RNAシーケンス解析を用いた多発性骨髄腫が持つ薬剤感受性遺伝子の探索

土師正二郎, 増田徹, 牟田宏樹, 小川佳宏

日本内科学会雑誌, 112, 2023
自然免疫受容体Dectin-1のO型糖鎖修飾依存的な新しい機能

伊藤泰紀, 伊藤泰紀, 土師正二郎, 土師正二郎, 土師正二郎, 中の三弥子, 長江雅倫, 長江雅倫, 山崎晶, 山崎晶

日本生化学会大会(Web), 95th, 2022
治療により下垂体前葉機能の改善を得た下垂体原発Burkittリンパ腫の一例

山下彩織, 坂本竜一, 甲斐田実里, 永井博史, 牟田宏樹, 土師正二郎, 松田やよい, 中嶋康博, 小川佳宏

日本内分泌学会雑誌, 97(4) 1033-1033, Dec, 2021
A case report of Burkitt’s lymphoma with hypopituitarism

牟田宏樹, 土師正二郎, 大山真, 津田麻理子, 増田徹, 高松明子, 木村大作, 中嶋康博, 小川佳宏

日本血液学会学術集会抄録(Web), 83rd, 2021
結核菌を認識するあらたなC型レクチン受容体

西村直矢, 土師正二郎, 本園千尋

医学のあゆみ, 261(13), 2017
自家末梢血幹細胞移植後に自然脾破裂を合併した軽鎖沈着症

土師正二郎, 喜安純一, 立川義倫, 豊永次郎, 池田元彦, 津田麻理子, 塚本康寛, 小鶴三男, 油布祐二

臨床血液, 57(6) 754-759, Jun, 2016
R-Bendamustine療法が著効した再発難治リンパ形質細胞性リンパ腫の1例

大野博文, 土師正二郎, 高松明子, 田中絵美, 藤岡絵里子, 松島孝充, 白土基明, 高柳涼一

臨床血液, 56(5), 2015
UTIを契機に発見された膀胱結腸瘻の一例

土師正二郎, 土師正二郎, 達川政文, 岸原康浩, 田中信英, 小林良三

日本病院総合診療医学会雑誌, 2(1), 2011

Books and Other Publications

結核菌を認識するあらたなC型レクチン受容体

西村直矢, 土師正二郎, 本園千尋 (Role: Joint author)

Jun, 2017

Professional Memberships

Jan, 2023 - Present

日本内分泌学会
Nov, 2016 - Present

日本免疫学会
2014 - Present

日本造血細胞移植学会
Jan, 2013 - Present

日本内科学会
Dec, 2012 - Present

日本血液学会

Research Projects

オミクス解析を駆使した多発性骨髄腫における薬剤耐性機構の解明と治療標的の同定

令和 5 年度研究助成金, 一般財団法人貝原守一医学振興財団, Apr, 2024 - Mar, 2027
経時的 scRNA-seq 解析による多発性骨髄腫の薬剤反応性遺伝子の同定

成人病の病因・病態の解明に関する研究助成 (TMFC), 公益財団法人日本応用酵素協会, 2022 - 2025
多発性骨髄腫の経時的scRNA-seqによる薬剤耐性遺伝子の同定と臨床への応用

研究助成, 日本血液学会, Apr, 2023 - Mar, 2024
Identification of drug-resistance genes in multiple myeloma by longitudinal single cell RNA-sequencing

Apr, 2022 - Mar, 2024
多発性骨髄腫の経時的single cell RNA-seqによる新規薬剤耐性遺伝子の同定

医学研究資金助成, 一般財団法人臨床医学振興財団, Jan, 2022 - Mar, 2024
多発性骨髄腫の経時的single cell RNA-seqによる新規薬剤耐性遺伝子の同定

臨床研究助成, 公益財団法人臨床研究奨励基金, Nov, 2021 - Mar, 2024
多発性骨髄腫の経時的scRNA-seqによる薬剤耐性遺伝子の同定と臨床への応用

研究助成, 日本血液学会, Apr, 2022 - Mar, 2023
Identification of drug resistant genes by longitudinal single cell RNA-seq

research grant, Daiwa Securities Health Foundation, Oct, 2021 - Oct, 2022
多発性骨髄腫の経時的シングルセル解析による新規治療反応予測マーカーの同定

ＱＲプログラムわかばチャレンジ, 九州大学, Apr, 2021 - Mar, 2022
再生不良性貧血におけるヒト骨髄MAIT細胞の機能解析

QRプログラムわかばチャレンジ, 九州大学, Oct, 2020 - Mar, 2021

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Education

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Papers

Misc.

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