HAMAGUCHI Michinari

J-GLOBAL         Last updated: Dec 28, 2015 at 14:25
 
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Name
HAMAGUCHI Michinari
Affiliation
Japan Science and Technology Agency
Job title
President

Research Areas

 

Research Interests

 
 

Published Papers

 
Akter KA, Mansour MA, Hyodo T, Ito S, Hamaguchi M, Senga T
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine      Oct 2015   [Refereed]
Obayashi T, Funasaka K, Ohno E, Miyahara R, Hirooka Y, Hamaguchi M, Goto H, Senga T
Oncology letters   10(3) 1836-1840   Sep 2015   [Refereed]
Maeda M, Hasegawa H, Sugiyama M, Hyodo T, Ito S, Chen D, Asano E, Masuda A, Hasegawa Y, Hamaguchi M, Senga T
FASEB journal : official publication of the Federation of American Societies for Experimental Biology      Sep 2015   [Refereed]
Ayesha AK, Hyodo T, Asano E, Sato N, Mansour MA, Ito S, Hamaguchi M, Senga T
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine      Aug 2015   [Refereed]
Yuan H, Kajiyama H, Ito S, Chen D, Shibata K, Hamaguchi M, Kikkawa F, Senga T
Oncotarget   6(15) 13359-13370   May 2015   [Refereed]

Misc

 
Hong Yuan, Hiroaki Kajiyama, Satoko Ito, Dan Chen, Kiyosumi Shibata, Michinari Hamaguchi, Fumitaka Kikkawa, Takeshi Senga
Oncotarget   6 1-12   Jan 2015
Homeoproteins, a family of transcription factors that have conserved homeobox domains, play critical roles in embryonic development in a wide range of species. Accumulating studies have revealed that homeoproteins are aberrantly expressed in multi...
HAMAGUCHI MICHINARI
共済医報   63(Supplement) 64   Oct 2014
ALX1は卵巣癌においてSnailの発現を誘導し、上皮間葉移行と浸潤を促進する(ALX1 induces snail expression to promote epithelial-tomesenchymal transition and invasion of ovarian cancer cells)
袁 紅, 梶山 広明, 伊藤 聡子, 芳川 修久, 柴田 清住, 前田 真男, 浜口 道成, 吉川 史隆, 千賀 威
日本癌学会総会記事   72回 174-174   Oct 2013
Aurora BによるSHCBP1のリン酸化は収縮環の収縮を制御する(The Aurora B-mediated phosphorylation of SHCBP1 regulates cleavage furrow ingression)
千賀 威, 伊藤 聡子, 浜口 道成
日本癌学会総会記事   72回 114-114   Oct 2013
Michinari Hamaguchi
Journal of the Institute of Electrical Engineers of Japan   133 131   May 2013

Books etc

 
足場依存細胞増殖制御システムの研究
浜口 道成
[s.n.]   2006   
Analysis of nuclear accumulation of influenza nucleoprotein antigen in the presence of p-fluorophenylalanine
浜口 道成
[s.n.]   1980   

Research Grants & Projects

 
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(特定領域研究)
Project Year: 2005 - 2009    Investigator(s): Michinari HAMAGUCHI
The Src kinase is often activated in breast cancer and colon cancer. We have been investigating the mechanisms of how Src kinase activates MMP secretion and enhances cell invasion. We have found cytokines such as TNFalpha and IL-1beta activated Sr...
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(基盤研究(C))
Project Year: 2007 - 2008    Investigator(s): Michinari HAMAGUCHI
一酸化窒素は多くの蛋白の活性を制御し、様々な生理的役割を担っている。我々は非受容体型チロシンキナーゼが、一酸化窒素によるニトロソ化により、活性が制御されることを見出した。Src, FAKは一酸化窒素により活性化されるが、その活性化には保存されたシステインのニトロソ化が重要であった。このニトロソ化による活性化は細胞間接着の制御や、癌細胞の浸潤、転移に関わっていることを明らかにした。
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(基盤研究(C))
Project Year: 2006 - 2008    Investigator(s): Koji ODA
cancer stem cell markerを用いた癌組織における免疫組織学的染色の結果, Cancer stem cellおよびprogenitor cellを多く発現した腫瘍は治療抵抗性で予後不良であることが示された.再発進行癌患者の末梢血液中に浮遊する癌細胞を採取し, cancer stem cell markerが陽性である癌細胞が同定された.
Japan Science and Technology Agency: CREST
Project Year: 2005 - 2007    Investigator(s): HAMAGUCHI Michinari
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(基盤研究(A))
Project Year: 2004 - 2007    Investigator(s): Yuji NIMURA
Cholangiocarcinoma, one of the most common liver tumors in South-east Asian countries, is a primary malignancy derived from the bile duct epithelium. Despite the progress of the combined therapy, its prognosis is still extremely miserable among al...